The pharmaceutical industry relies heavily on a consistent supply of high-quality chemical intermediates to develop and manufacture life-saving medications. Among these critical compounds is 4,7-Dichloroquinoline (CAS 86-98-6), a vital precursor with significant applications, particularly in the field of antimalarial drug synthesis. Understanding its chemical properties, synthesis routes, and application scope is essential for researchers, formulators, and procurement specialists.

Chemical Profile: 4,7-Dichloroquinoline

4,7-Dichloroquinoline, identified by CAS number 86-98-6, is an organic compound belonging to the quinoline family. Its molecular formula is C9H5Cl2N, with a molecular weight of approximately 198.05 g/mol. Typically presented as a white to light yellow crystalline powder, this compound is sparingly soluble in water but exhibits solubility in various organic solvents. Its structure features a quinoline core substituted with chlorine atoms at the 4 and 7 positions, which dictates its chemical reactivity and utility.

Synthesis Pathways

The synthesis of 4,7-Dichloroquinoline has been a subject of significant research to ensure efficient and cost-effective production. One common method involves the chlorination of 7-chloro-4-hydroxyquinoline using phosphoryl chloride (POCl3). This reaction typically proceeds under reflux conditions, followed by neutralization and crystallization to isolate the desired product. For instance, adding 4-hydroxy-7-chloroquinoline to excess phosphorus oxychloride and refluxing for a period can yield 4,7-Dichloroquinoline with good efficiency. The availability of reliable synthesis methods is crucial for manufacturers aiming to supply this intermediate consistently.

Primary Pharmaceutical Applications

The most prominent application of 4,7-Dichloroquinoline is its role as a key intermediate in the synthesis of 4-aminoquinoline antimalarial drugs. These drugs are vital in the global fight against malaria, a disease that continues to affect millions worldwide. Specifically, 4,7-Dichloroquinoline serves as the foundational component for:

  • Chloroquine: A widely used antimalarial and anti-inflammatory drug.
  • Hydroxychloroquine: Also used for malaria and autoimmune diseases like rheumatoid arthritis and lupus.
  • Amodiaquine: Another important antimalarial medication.

The chlorine atom at the 4-position of the quinoline ring is highly reactive towards nucleophilic substitution, allowing for the facile introduction of diamine side chains. This chemical characteristic makes 4,7-Dichloroquinoline an ideal precursor for these crucial APIs. Researchers also explore its utility in developing novel drug candidates and chemical entities with potential therapeutic benefits.

Why Partner with a Dedicated Supplier?

For businesses looking to purchase 4,7-Dichloroquinoline, partnering with a specialized chemical supplier is essential. Companies like NINGBO INNO PHARMCHEM CO.,LTD. offer expertise in producing and supplying high-quality pharmaceutical intermediates. They ensure:

  • Guaranteed Purity: Meeting stringent pharmaceutical standards.
  • Consistent Supply: Reliable production capacity to meet demand.
  • Technical Support: Expert guidance on product usage and specifications.
  • Competitive Pricing: Cost-effective solutions for bulk orders.

By leveraging the capabilities of experienced manufacturers and suppliers, pharmaceutical companies can secure a stable and high-quality source of 4,7-Dichloroquinoline, thereby streamlining their manufacturing processes and contributing to the availability of essential medicines.