For chemists and R&D scientists, a deep understanding of the technical specifications and reactivity of chemical intermediates is key to optimizing synthesis yields and developing efficient processes. 2-Bromo-3-fluorobenzonitrile (CAS 425379-16-4) is a compound that offers significant versatility, thanks to its unique structural features. This article provides a technical overview of the compound and guidance on how to source it effectively.

Understanding the Technical Profile: 2-Bromo-3-fluorobenzonitrile, with the molecular formula C7H3BrFN and a molecular weight of 200.01 g/mol, is identified by its CAS number 425379-16-4. It typically presents as a solid. Key physical properties that are vital for its use in synthesis include:

  • Melting Point (MP): 60.2-61.3℃. This relatively low melting point indicates that it can be handled and potentially melted for certain reactions without excessive heating.
  • Boiling Point (BP): 252.8℃ at 760mmHg. This high boiling point suggests it has good thermal stability under standard atmospheric pressure, important for reactions requiring elevated temperatures.
  • Flash Point (FP): 106.7℃. The flash point indicates the temperature at which it can vaporize to form an ignitable mixture in air, providing safety information for handling.
  • Density: 1.69 g/cm³. This density value is useful for mass-to-volume conversions in reaction planning.
  • Purity: Typically specified as 97% Min. High purity is essential to minimize side reactions and ensure predictable results in complex syntheses.

Reactivity and Synthetic Utility: The presence of three key functional groups—a nitrile, a bromine atom, and a fluorine atom—on an aromatic ring makes 2-Bromo-3-fluorobenzonitrile a highly versatile intermediate. The nitrile group can undergo hydrolysis, reduction, or cycloaddition. The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Sonogashira, Buchwald-Hartwig amination), allowing for the introduction of carbon-carbon or carbon-heteroatom bonds. The fluorine atom can influence electronic properties, lipophilicity, and metabolic stability of the final product, which is particularly beneficial in pharmaceutical and agrochemical applications.

Sourcing and Procurement: When you need to buy 2-Bromo-3-fluorobenzonitrile, partnering with a reliable manufacturer is crucial. Suppliers like NINGBO INNO PHARMCHEM CO.,LTD., based in China, offer this intermediate with high purity and competitive pricing. When inquiring, ask for detailed technical specifications, safety data sheets (SDS), and Certificates of Analysis (CoA). Understanding the supplier's manufacturing capabilities and quality control processes will assure you of receiving a consistent and high-quality product for your demanding synthetic requirements. Obtaining samples can also be a wise step before placing larger orders.

By understanding the technical profile and reactivity of 2-Bromo-3-fluorobenzonitrile, researchers can more effectively plan and execute their synthetic strategies, leading to more efficient processes and novel discoveries. Reliable sourcing from qualified manufacturers ensures that these efforts are built upon a foundation of quality.