For researchers pushing the boundaries in chemistry, biology, and materials science, understanding the utility of specialized chemical intermediates is crucial. 2-[2-(2-methoxyethoxy)ethoxy]ethylamine, identified by CAS: 74654-07-2 and commonly known as mPEG3-Amine, is one such versatile molecule. Its unique combination of a short polyethylene glycol (PEG) chain and a terminal amine group makes it an invaluable tool for a variety of scientific investigations, from drug delivery systems to biomaterial functionalization.

The physical and chemical properties of mPEG3-Amine contribute significantly to its broad applicability. As an oil, typically colorless to light yellow, it exhibits excellent solubility in both water and common organic solvents, a characteristic derived from its hydrophilic PEG backbone. The molecular weight of approximately 163.22 g/mol, coupled with a pKa of around 8.74, further defines its behavior in chemical reactions and biological environments. The terminal primary amine group (NH2) is nucleophilic and readily participates in a wide range of reactions, including amidation with carboxylic acids, reaction with activated esters, and Schiff base formation with aldehydes and ketones. This reactivity makes it an ideal choice for conjugation chemistry.

One of the primary applications for mPEG3-Amine is in the field of drug delivery. Its incorporation into nanocarriers or drug conjugates can enhance their circulation time, improve targeting efficiency, and increase the solubility of hydrophobic drugs. The PEG chain acts as a stealth layer, reducing opsonization and uptake by the immune system. Researchers often buy mPEG3-Amine to functionalize nanoparticles, liposomes, or to create PEGylated drug molecules, aiming to optimize their pharmacokinetic profiles.

Beyond drug delivery, mPEG3-Amine is extensively used in biomaterial science for surface modification. By grafting this molecule onto surfaces of medical implants, biosensors, or diagnostic assays, researchers can create biocompatible interfaces that resist protein fouling and cell adhesion. This is particularly important for devices intended for long-term implantation or continuous monitoring. When seeking to buy mPEG3-Amine for such applications, ensuring high purity and consistent quality from a reliable manufacturer, particularly those in China, is paramount.

The synthesis of mPEG3-Amine is typically achieved through established chemical routes, ensuring its availability for research purposes. The demand for this intermediate is driven by its critical role in creating advanced molecules for pharmaceutical and biotechnological applications. For scientists and procurement specialists looking to source CAS: 74654-07-2, engaging with experienced chemical suppliers who understand the rigorous requirements of research-grade chemicals is essential. The competitive pricing offered by many manufacturers makes this versatile compound accessible for both academic and industrial laboratories.