In the dynamic field of custom peptide synthesis, precision and versatility are key. Chemists constantly seek advanced building blocks that can facilitate the construction of complex peptide architectures and introduce specific functionalities. Among these essential reagents, Fmoc-L-Lys(Dde)-OH stands out for its unique properties, particularly its role in enabling selective modifications of the lysine side chain.

Fmoc-Lys(Dde)-OH is a protected lysine derivative widely used in Fmoc solid-phase peptide synthesis (SPPS). The Fmoc group on the alpha-amino terminus ensures controlled chain elongation, while the Dde group on the epsilon-amino terminus provides a means for orthogonal protection. This means the Dde group can be removed independently of the Fmoc group, typically using hydrazine or hydroxylamine. This selective deprotection is fundamental to achieving complex peptide structures that would otherwise be challenging to synthesize.

One of the primary applications of Fmoc-Lys(Dde)-OH in custom peptide synthesis is the preparation of branched peptides. Once the main peptide backbone is synthesized using standard Fmoc SPPS protocols, the Dde group can be selectively cleaved from the lysine side chain. This unmasks the epsilon-amino group, allowing for the attachment of a second peptide chain. This capability is invaluable for creating molecules like peptide dendrimers, multiple antigen peptides (MAPs), or for constructing combinatorial peptide libraries for screening purposes.

Another significant application lies in the synthesis of cyclic peptides. Lysine's epsilon-amino group can be utilized to form a macrocyclic ring, often by coupling it to another reactive site within the peptide chain. Fmoc-Lys(Dde)-OH is the reagent of choice for introducing this lysine residue when such cyclization strategies are planned. The ability to selectively deprotect the Dde group at the desired stage ensures that the cyclization reaction can be carried out efficiently without interfering with the ongoing synthesis.

The purity of Fmoc-Lys(Dde)-OH is a critical factor for custom peptide synthesis providers. High purity, often exceeding 99.0%, guarantees the integrity of the synthesized peptide and minimizes the formation of unwanted byproducts. This attention to detail is what distinguishes a premium custom peptide synthesis service.

When considering the purchase of Fmoc-Lys(Dde)-OH, it is essential to partner with reliable suppliers who specialize in amino acid derivatives and reagents for peptide synthesis. The price of Fmoc-Lys(Dde)-OH reflects its specialized nature and high purity, making it a valuable investment for laboratories undertaking demanding custom synthesis projects. For those looking to buy Fmoc-Lys(Dde)-OH, understanding its role in achieving complex peptide targets underscores its importance in the custom synthesis workflow. The CAS number 150629-67-7 is a key identifier for this crucial building block.