5-Chloro-Uracil Bulk Price Global Manufacturer Quote
- Direct Factory Supply: Access competitive bulk price tiers directly from NINGBO INNO PHARMCHEM CO.,LTD. without intermediary markups.
- Technical Grade Purity: Specifications exceed 98.5% purity with comprehensive COA and SDS documentation for regulatory compliance.
- Global Logistics: Optimized shipping solutions for hazardous chemicals ensuring safe delivery for 2026 supply chains.
5-Chloro-Uracil, chemically known as 5-chloro-1H-pyrimidine-2,4-dione, is a critical pyrimidine analog utilized extensively in pharmaceutical development and biochemical research. As a halogenated derivative of uracil, this compound serves as a fundamental building block for nucleoside analogs used in antiviral and antineoplastic therapies. For procurement managers and synthetic chemists, securing a reliable supply chain with consistent industrial purity is paramount to maintaining reaction yields and final drug efficacy.
At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in the large-scale production of heterocyclic intermediates. Our manufacturing capabilities are designed to meet the rigorous demands of the global pharmaceutical market, ensuring that every batch of 5-Chloro-uracil meets strict quality control standards. This article provides a detailed technical overview, commercial pricing structure, and logistics framework for sourcing this essential intermediate.
Technical Specifications and Synthesis Route
The production of high-quality 5-Chlorouracil requires precise control over the chlorination process to minimize di-chlorinated impurities and ensure consistent particle size distribution. Our preferred synthesis route involves the direct chlorination of uracil using chlorinating agents under controlled acidic conditions. This method is optimized to maximize yield while reducing waste byproducts, aligning with green chemistry principles.
Below is the standard technical specification sheet for our bulk supply:
| Property | Specification |
| Chemical Name | 5-Chloro-1H-pyrimidine-2,4-dione |
| CAS Number | 1820-81-1 |
| Molecular Formula | C4H3ClN2O2 |
| Molecular Weight | 146.53 g/mol |
| Purity (HPLC) | ≥ 98.5% |
| Appearance | White to off-white crystalline powder |
| Loss on Drying | ≤ 0.5% |
| Heavy Metals | ≤ 10 ppm |
Quality assurance is maintained through rigorous analytical testing. Every shipment is accompanied by a COA (Certificate of Analysis) that verifies identity, purity, and residual solvent levels. For researchers evaluating suppliers, comparing these technical data points is essential when determining the suitability of the material for sensitive downstream synthesis.
Commercial Applications and Market Demand
The demand for this pyrimidine derivative is driven by its utility in several high-value sectors. In medicinal chemistry, it is a key precursor for fluorinated pyrimidines used in cancer treatment. Its ability to inhibit DNA synthesis makes it effective against rapidly dividing cells, positioning it as a vital component in chemotherapeutic agent development.
Additionally, the compound is employed in antiviral research to explore efficacy against viral infections by disrupting replication mechanisms. In biochemical studies, laboratories utilize it to investigate nucleic acid metabolism and the effects of pyrimidine analogs on cellular processes. When sourcing high-purity 5-Chlorouracil, buyers should ensure the supplier can provide batch-specific documentation to support regulatory filings such as DMFs or IMPDs.
Bulk Pricing Tiers vs Retail Pack Costs
Procurement strategies for pharmaceutical intermediates differ significantly between laboratory scale and commercial manufacturing. Retail pack costs often include premiums for small quantity handling, packaging, and immediate availability. In contrast, bulk procurement offers substantial cost reductions per kilogram, particularly for contracts securing future production capacity.
Our bulk price structure is tiered based on volume commitments:
- R&D Scale (1kg - 10kg): Premium pricing includes expedited handling and small-batch QC testing.
- Pilot Scale (10kg - 100kg): Reduced rates applicable for process development and clinical trial material synthesis.
- Commercial Scale (100kg+): Most competitive pricing tailored for long-term manufacturing agreements.
As a verified global manufacturer, we offer price stability clauses for annual contracts, protecting buyers from raw material volatility. This is particularly important for projects extending into 2026, where supply chain consistency is as valuable as unit cost.
Global Logistics and Shipping Options
Shipping chemical intermediates requires adherence to international safety regulations. 5-Chloro-Uracil is generally classified for transport under standard hazardous material guidelines depending on the specific formulation and packaging. We utilize robust packaging solutions, including double-lined fiber drums with polyethylene inner bags, to prevent moisture uptake and contamination during transit.
Logistics options include:
- Express Courier: Suitable for urgent R&D samples (3-5 days delivery).
- Air Freight: Balanced speed and cost for pilot batches (7-10 days delivery).
- Sea Freight (FCL/LCL): Most cost-effective solution for commercial bulk orders (25-35 days delivery).
All shipments include necessary documentation such as Safety Data Sheets (SDS), Certificates of Origin (COO), and packing lists to ensure smooth customs clearance. Our logistics team coordinates with freight forwarders to manage DDP (Delivered Duty Paid) or FOB (Free on Board) terms based on buyer preference.
Request Quote Procedure for 2026 Supply
To initiate a procurement inquiry, buyers should submit a formal Request for Quotation (RFQ) detailing the required volume, target purity, and destination port. Our sales team at NINGBO INNO PHARMCHEM CO.,LTD. responds within 24 hours with a comprehensive proposal including technical data sheets and commercial terms.
For long-term supply planning, we recommend establishing a framework agreement early. This secures production slots in our manufacturing schedule and locks in pricing parameters. We encourage potential partners to request samples for internal validation before committing to large-scale orders. Our technical support team is available to assist with application-specific queries regarding solubility, reactivity, and storage requirements.
In conclusion, securing a reliable source for 5-Chloro-Uracil involves balancing technical specifications with commercial viability. By partnering with an experienced manufacturer, pharmaceutical companies can ensure consistent quality and supply continuity for their critical drug development pipelines.