In the synthesis of oncology APIs, the Buchwald-Hartwig amination stands as a cornerstone for constructing critical C-N bonds. When employing halogenated anilines such as 2-bromo-3-fluoroaniline (CAS 111721-75-6), also referred to as 2-bromo-3-fluorophenylamine or 3-fluoro-2-bromoaniline, the reaction's success hinges on meticulous control of solvent, temperature, and impurities. This article provides field-tested strategies for R&D managers scaling up these reactions, with a focus on the unique challenges posed by this bromofluoroaniline intermediate.
