Drop-In Replacement For TCI A1842: 5-Iodopyridin-2-Amine Bulk
Trace Halide Impurities and Catalyst Poisoning: ICP-MS Verified Metal Limits for Suzuki-Miyaura Couplings
In palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings, the presence of trace halide impurities and heavy metals can severely poison catalysts, leading to reduced yields and inconsistent results. For procurement managers sourcing 5-iodopyridin-2-amine as a drop-in replacement for TCI America A1842, understanding the impact of these impurities is critical. Our product, manufactured by NINGBO INNO PHARMCHEM CO.,LTD., undergoes rigorous ICP-MS analysis to verify metal limits, ensuring that residual palladium, iron, and other transition metals are maintained at levels that do not interfere with sensitive catalytic cycles. Unlike standard lab-grade material, our bulk specifications include a dedicated trace metals report, which is essential for process chemists scaling up reactions. A common non-standard parameter we monitor is the presence of trace copper, which can originate from halogen exchange steps during synthesis. Even at sub-ppm levels, copper can facilitate undesired homocoupling in Suzuki reactions. Our field experience shows that controlling copper below 5 ppm significantly improves coupling efficiency. For detailed batch-specific data, please refer to the batch-specific COA.
Batch-to-Batch Consistency in Assay and Purity: Preventing Palladium Catalyst Deactivation
Consistency is paramount when replacing a trusted reagent like TCI A1842. Our 5-iodo-2-pyridinamine is produced under strict quality control to ensure that each batch meets or exceeds the ≥98.0% purity (GC, T) specification typical of the original product. However, assay alone does not tell the whole story. We have observed that certain organic impurities, such as dehalogenated byproducts (e.g., 2-aminopyridine), can act as ligands that coordinate to palladium and deactivate the catalyst. Our manufacturing process minimizes these impurities, and we provide a detailed impurity profile upon request. For R&D managers, this means you can confidently scale up without re-optimizing reaction conditions. As a reliable source of 5-iodopyridin-2-amine, we ensure that the physical form—a white crystalline powder—and melting point (127°C) are consistent, avoiding issues with variable crystallinity that can affect dissolution rates in reaction solvents.
Physical and Chemical Specifications: Melting Point, Crystalline Form, and Storage Stability
The following table compares the key technical parameters of our product with the typical specifications of TCI America A1842, demonstrating equivalence as a drop-in replacement.
| Parameter | TCI A1842 (Typical) | NINGBO INNO PHARMCHEM |
|---|---|---|
| CAS Number | 20511-12-0 | 20511-12-0 |
| Molecular Formula | C5H5IN2 | C5H5IN2 |
| Molecular Weight | 220.01 | 220.01 |
| Purity (GC, T) | ≥98.0% | ≥98.0% (typical >99%) |
| Melting Point | 127°C | 127–129°C |
| Physical Form | Crystalline Powder | White to off-white crystalline powder |
| Storage Condition | Refrigerator, protect from light | Store at 2–8°C, protect from light and moisture |
| Trace Metals (ICP-MS) | Not routinely reported | Available: Pd, Fe, Cu <10 ppm each |
Storage stability is a critical factor often overlooked in bulk procurement. This pyridine derivative is sensitive to light, heat, and air. We have observed that prolonged exposure to ambient conditions can lead to slight discoloration (yellowing) without significant assay loss, but this can be a concern for applications requiring colorless intermediates. Our packaging in amber glass or opaque containers under inert atmosphere mitigates this. For bulk shipments, we use sealed IBCs or 210L drums with nitrogen blanketing to ensure product integrity during transit and storage.
Bulk Packaging and Supply Chain Reliability: IBC and 210L Drum Options for Industrial Scale
For industrial-scale procurement, packaging and logistics are as important as chemical specifications. NINGBO INNO PHARMCHEM offers 5-iodo-2-aminopyridine in bulk quantities with flexible packaging options, including 210L steel drums and intermediate bulk containers (IBCs). Our standard drum holds 25 kg net weight, while IBCs can accommodate up to 500 kg. All packaging complies with international transport regulations for solid chemicals. We do not claim EU REACH compliance, but our packaging is designed to prevent contamination and moisture ingress. Our supply chain is robust, with multiple production lines and safety stock maintained for this heterocyclic compound. Lead times for bulk orders are typically 2–4 weeks, and we provide full documentation including COA, SDS, and packing lists. For those evaluating alternatives, our article on drop-in replacement for Thermo Fisher B25175 offers additional insights into cross-compatibility. Similarly, our German-language resource Drop-In-Ersatz für Thermo Fisher B25175 covers the same topic for European clients.
Frequently Asked Questions
What trace metal limits are specified in your COA for 5-iodopyridin-2-amine?
Our standard COA includes ICP-MS data for palladium (Pd), iron (Fe), and copper (Cu), with limits typically below 10 ppm each. Additional metals can be tested upon request. This is crucial for catalyst compatibility in cross-coupling reactions.
How does your product perform in Suzuki-Miyaura couplings compared to TCI A1842?
Our 2-amino-5-iodopyridine is a direct drop-in replacement. In side-by-side tests, coupling efficiency and yield are equivalent, provided the catalyst system is not poisoned by trace impurities. Our low metal content ensures consistent performance.
Is there any variation in assay between lab-scale and bulk quantities?
We maintain a minimum purity of 98.0% by GC and titration for all package sizes. Bulk material may exhibit a slightly higher assay (>99%) due to scale-up optimization, but we guarantee the specification. Please refer to the batch-specific COA for exact values.
What is the pKa of 2-amino pyridine?
The pKa of the conjugate acid of 2-aminopyridine is approximately 6.8. This value is relevant for understanding the basicity of the pyridine nitrogen in related compounds, though the iodo substituent in 5-iodopyridin-2-amine will lower the pKa slightly due to its electron-withdrawing effect.
What is the CAS number of 2-amino-5-chloropyridine?
The CAS number of 2-amino-5-chloropyridine is 1072-98-6. This compound is a related halogenated pyridine derivative often used in similar synthetic applications.
Sourcing and Technical Support
As a global manufacturer of 5-iodopyridin-2-amine, NINGBO INNO PHARMCHEM is committed to providing a seamless drop-in replacement for TCI A1842 with identical technical parameters, enhanced trace metal documentation, and reliable bulk supply. Our team of chemical engineers is available to discuss your specific synthesis route and provide supporting data to ensure a smooth transition. To request a batch-specific COA, SDS, or secure a bulk pricing quote, please contact our technical sales team.