2,8-Bis(Trifluoromethyl)-4-Quinolinol Bulk Price Quote 2026
- Industrial Purity: Consistent assay ranges of 98.5% minimum verified by HPLC.
- Supply Security: Scalable manufacturing process capable of meeting KG-scale demand.
- 2026 Forecast: Stable bulk pricing structures available for long-term procurement contracts.
The demand for specialized fluorinated intermediates continues to rise within the pharmaceutical and agrochemical sectors. Specifically, 2,8-Bis(trifluoromethyl)-1H-quinolin-4-one (CAS: 35853-41-9) represents a critical pharmaceutical building block utilized in the development of advanced therapeutic agents. As we approach 2026, procurement strategies must shift from spot buying to secured supply chains that guarantee both technical consistency and commercial viability. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier global manufacturer dedicated to providing these high-value intermediates with rigorous quality control.
This compound, often referred to technically as 2,8-Bis(trifluoromethyl)quinolin-4-ol, possesses unique structural properties that enhance metabolic stability in drug candidates. The introduction of trifluoromethyl groups at the 2 and 8 positions of the quinoline ring significantly alters the electronic distribution, making it an invaluable organic intermediate for medicinal chemistry programs. Sourcing this material requires a partner who understands the nuances of fluorination chemistry and can deliver high purity batches consistently.
Technical Specifications and Quality Standards
Industrial procurement relies on precise data. Based on standard industry specifications and internal quality controls, the material must meet strict physicochemical parameters. The following table outlines the critical quality attributes expected for bulk orders.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 35853-41-9 | N/A |
| Molecular Formula | C11H5F6NO | N/A |
| Formula Weight | 281.15 g/mol | Calculation |
| Assay (Purity) | 98.5% Min | HPLC |
| Melting Point | 130.0°C to 134.0°C | DSC / Capillary |
| Appearance | Colorless to Yellow Solid | Visual |
| Infrared Spectrum | Conforms to Structure | FTIR |
Maintaining the melting point range between 130.0°C and 134.0°C is a key indicator of crystalline purity. Deviations often suggest the presence of isomeric impurities or incomplete reaction byproducts. Every batch produced by NINGBO INNO PHARMCHEM CO.,LTD. is accompanied by a comprehensive COA (Certificate of Analysis), ensuring full traceability from raw materials to the final packaged product. This documentation is essential for regulatory filings and quality assurance audits.
Synthesis Route and Manufacturing Process
The manufacturing process for this quinolinol derivative typically involves the cyclization of appropriate aniline precursors with beta-keto esters or acids, followed by specific trifluoromethylation steps. Achieving the 2,8-bis substitution pattern requires precise control over reaction conditions to prevent mono-substitution or over-fluorination. Optimization of these reaction yields is critical for cost-effective bulk production.
Industrial scale-up introduces challenges regarding heat dissipation and mixing efficiency, particularly during exothermic fluorination stages. Advanced reactor setups are employed to maintain thermal stability, ensuring that the final 2,8-Bis(trifluoromethyl)-4-quinolinol meets the required assay percent range without degradation. When sourcing high-purity fluorinated quinoline derivative, buyers should verify that the supplier utilizes robust purification techniques, such as recrystallization or column chromatography, to remove trace halogenated impurities.
Volume-Based Pricing Tiers for Bulk Orders
Procurement costs are heavily influenced by order volume and purification requirements. The following pricing structure reflects typical market expectations for 2026, assuming standard packaging and delivery terms.
| Quantity Tier | Packaging Format | Estimated Lead Time | Commercial Terms |
|---|---|---|---|
| 100g - 1kg | Glass Bottle / Foil Bag | 3-5 Days | Standard Catalog Price |
| 1kg - 10kg | Double LDPE Bag + Drum | 7-14 Days | Volume Discount Applied |
| 10kg - 100kg | Fiber Drum / Custom | 14-21 Days | Negotiated Bulk Price |
| 100kg+ | Bulk Container | 30 Days | Contract Manufacturing |
For quantities exceeding 10kg, clients are encouraged to request a custom quote. Blanket purchase orders are accepted for large quantities, allowing buyers to lock in rates against market volatility. Sharing target price and specific requirements facilitates a quicker response to bulk quantity requests.
MOQ Requirements and Packaging Options
Minimum Order Quantities (MOQ) are structured to optimize production runs while accommodating R&D needs. Standard MOQs typically start at 100g for evaluation purposes. However, for commercial production, the MOQ aligns with the smallest viable reactor batch size, usually 1kg or higher. Packaging is designed to ensure stability during transit; moisture-sensitive materials are sealed under nitrogen atmosphere when necessary.
Safety and handling protocols dictate that the product be stored in a cool, dry place away from incompatible materials. The material carries a GHS Signal Word of Warning, with hazard statements indicating potential skin and eye irritation. Proper personal protective equipment (PPE), including gloves and eye protection, must be worn during handling. All shipping documentation complies with international transport regulations, ensuring smooth customs clearance.
2026 Market Forecast and Cost Analysis
Looking toward 2026, the bulk price of fluorinated intermediates is expected to stabilize as production capacities expand in key manufacturing hubs. However, raw material costs for fluorinating agents remain a variable factor. Strategic partnerships with established suppliers mitigate the risk of supply chain disruptions. The demand driven by oncology research and agricultural chemical development suggests a steady increase in consumption volume.
Investing in long-term supply agreements now provides a hedge against potential inflation in raw material costs. NINGBO INNO PHARMCHEM CO.,LTD. offers transparent pricing models that reflect actual production costs rather than speculative market rates. This approach ensures that partners receive competitive value without compromising on the industrial purity required for downstream synthesis.
Conclusion
Securing a reliable supply of 2,8-Bis(trifluoromethyl)-1H-quinolin-4-one is essential for maintaining continuity in pharmaceutical and material science projects. By prioritizing technical specifications, verified purity, and transparent commercial terms, buyers can ensure successful project outcomes. For detailed specifications or to initiate a procurement dialogue, contact the technical sales team to discuss your specific volume requirements and timeline.