Industrial Grade 3,4-Difluorobenzyl Chloride (CAS 698-80-6) Specifications
- Reaction Kinetics: Optimized chloromethylation routes ensure minimal halogenated impurities for downstream coupling.
- Logistical Assurance: Factory-direct tonnage quantities available with verified cold-chain shipping protocols.
- Audit Readiness: Full regulatory documentation packages including REACH compliance and batch-specific COA.
In the landscape of modern pharmaceutical manufacturing, the reliability of fluorinated building blocks dictates the success of complex synthesis pipelines. 3,4-Difluorobenzyl Chloride (CAS 698-80-6) serves as a critical fluorinated intermediate for the production of advanced agrochemicals and medicinal compounds. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. delivers this aromatic building block with consistent industrial purity, ensuring that process chemists can maintain high reaction yields without extensive purification burdens.
Synthetic Route and Impurity Profile
For R&D teams evaluating this C7H5ClF2 species, understanding the manufacturing process is vital for predicting downstream reactivity. The compound, also known synonymously as 4-(chloromethyl)-1,2-difluorobenzene, is typically produced via the chloromethylation of 3,4-difluorotoluene. Controlling the reaction temperature and stoichiometry is essential to minimize the formation of bis-chloromethylated byproducts and ring-chlorinated impurities.
Our production methodology focuses on maximizing the assay percentage while keeping specific impurities below detection limits required for GMP environments. When sourcing high-purity 3,4-Difluorobenzyl Chloride, buyers should prioritize suppliers who utilize vacuum distillation to achieve the necessary separation from unreacted starting materials. This level of control ensures the material remains a clear colorless to faintly yellow liquid, suitable for sensitive nucleophilic substitution reactions.
Technical Specifications and Quality Parameters
Procurement officers require precise data to validate incoming materials against internal quality standards. The following table outlines the critical physical and chemical properties expected from commercial grade supplies. Consistency in these parameters is non-negotiable for maintaining batch-to-batch consistency in final drug substances.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 698-80-6 | N/A |
| Molecular Formula | C7H5ClF2 | N/A |
| Molecular Weight | 162.56 g/mol | Calculated |
| Assay (Purity) | ≥ 98.0% | GC / HPLC |
| Appearance | Clear colorless to faintly yellow liquid | Visual |
| Boiling Point | 27-29 °C (at 0.4 mmHg) | Distillation |
| Refractive Index | 1.490 - 1.494 (20 °C) | Refractometry |
| Density | 1.294 g/cm³ | Pychnometry |
Supply Chain Stability and Commercial Viability
For executives managing production budgets, securing a stable supply chain is as important as the chemical specifications themselves. Market volatility can impact bulk price structures, particularly for halogenated intermediates subject to strict environmental regulations. Partnering with an established entity like NINGBO INNO PHARMCHEM CO.,LTD. mitigates these risks through vertically integrated manufacturing capabilities.
We offer custom packaging solutions ranging from laboratory scales to ISO tank containers, ensuring that logistics do not become a bottleneck for your production schedule. Every shipment is accompanied by a comprehensive COA (Certificate of Analysis) and Safety Data Sheet (SDS), facilitating smooth customs clearance and internal quality assurance verification. Our commitment to regulatory compliance, including REACH and TSCA standards, ensures that your commercial operations remain uninterrupted by regulatory hurdles.
Request Technical Documentation
To ensure this material meets your specific process requirements, we invite you to contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote. Our experts are ready to discuss synthesis scalability and provide the documentation necessary for your vendor qualification process.