3-Bromo-1-Phenyl-5-(Pyridin-2-Yl)Pyridin-2-One Bulk Price 2026
- Market Forecast: Bulk procurement costs are projected to stabilize in 2026 due to optimized synthesis routes and raw material availability.
- Quality Standards: Industrial purity exceeds 98% with comprehensive COA documentation including HPLC and NMR data.
- Supply Chain: Direct manufacturing capabilities ensure consistent lead times for large-scale pharmaceutical production.
The pharmaceutical landscape continues to demand high-quality heterocyclic compounds for advanced drug development. Specifically, the CAS 381248-06-2 molecule represents a critical Perampanel intermediate used in the synthesis of antiepileptic medications. As we approach 2026, procurement managers and process chemists must navigate fluctuating market dynamics to secure favorable bulk price agreements. Understanding the technical specifications and commercial variables associated with this compound is essential for maintaining cost-effective production lines.
At NINGBO INNO PHARMCHEM CO.,LTD., we recognize that reliable supply chains are the backbone of pharmaceutical manufacturing. This article provides a detailed analysis of pricing structures, technical synthesis parameters, and logistics for sourcing this valuable chemical building block. By partnering with a dedicated global manufacturer, organizations can mitigate supply risks and ensure compliance with stringent quality protocols.
Technical Specifications and Synthesis Overview
The chemical structure of 3-Bromo-1-phenyl-5-(pyridin-2-yl)pyridin-2-one involves a complex pyridinone core substituted with bromine and phenyl groups. Achieving high industrial purity requires a robust synthesis route that minimizes byproduct formation, particularly isomeric impurities that can complicate downstream reactions. The molecular formula C16H11BrN2O and molecular weight of 327.18 g/mol dictate specific handling and storage requirements to prevent degradation.
Standard manufacturing processes typically involve bromination of the corresponding pyridinone precursor under controlled conditions. Process optimization focuses on maximizing reaction yields while maintaining selectivity. Advanced purification techniques, such as recrystallization or column chromatography, are employed to reach purity levels suitable for GMP standards. Analytical verification includes:
- HPLC Analysis: Confirming purity levels above 98.0%.
- NMR Spectroscopy: Verifying structural integrity and substitution patterns.
- Mass Spectrometry: Ensuring accurate molecular weight confirmation.
When evaluating potential suppliers, it is crucial to request a Certificate of Analysis (COA) that details these parameters. For comprehensive technical data sheets regarding 3-Bromo-1-phenyl-5-(pyridin-2-yl)pyridin-2-one, direct consultation with the manufacturing team is advised to ensure alignment with your specific process requirements.
Volume Discount Tiers for Bulk Orders
Pricing for fine chemicals varies significantly based on quantity. Market intelligence indicates that small-scale catalog purchases, often in the range of 2.5 grams, can carry unit prices exceeding $1,000 USD. This reflects the high cost of packaging, quality control, and logistics for research-scale quantities. However, industrial-scale procurement operates under a different economic model.
For bulk orders, typically defined as quantities exceeding 1 kilogram, the unit cost decreases substantially. Manufacturers offer tiered pricing structures that reward volume commitments. The following table outlines estimated pricing dynamics based on current market trends for 2026:
| Order Quantity | Estimated Unit Price Trend | Lead Time | Documentation |
|---|---|---|---|
| Research Scale (1g - 10g) | High (Premium Catalog Pricing) | Immediate Stock | Standard COA |
| Pilot Scale (100g - 500g) | Moderate Discount | 1-2 Weeks | Full Analytical Report |
| Bulk Production (1kg +) | Significant Volume Discount | 3-4 Weeks | GMP Documentation Available |
It is important to note that these prices are indicative. Final quotations depend on raw material costs, currency exchange rates, and specific purity requirements. Engaging directly with NINGBO INNO PHARMCHEM CO.,LTD. allows buyers to negotiate contracts that lock in pricing for future quarters, protecting against market volatility.
Global Shipping and Logistics Costs
Logistics play a pivotal role in the total landed cost of imported chemicals. As a hazardous material due to its chemical nature, proper classification and packaging are mandatory for international shipping. Air freight is typically utilized for urgent, smaller shipments, while sea freight offers cost savings for large-volume bulk orders.
Key logistics considerations include:
- Incoterms: Clarifying responsibilities for FOB, CIF, or DDP shipments.
- Customs Compliance: Ensuring HS codes are correctly classified to avoid delays.
- Packaging: Using double-lined drums or sealed containers to prevent moisture ingress.
Reliable manufacturers provide tracking information and handle export documentation efficiently. This reduces the administrative burden on the procurement team and ensures that materials arrive ready for immediate integration into the production workflow.
Payment Terms and Bulk Inquiry Process
Establishing a successful B2B relationship requires transparent payment terms. For new clients, standard terms often involve telegraphic transfer (T/T) with a deposit upon order confirmation. Established partners may qualify for more flexible arrangements, such as letters of credit (L/C) for significant volumes.
To initiate a bulk inquiry, buyers should prepare the following information:
- Target Quantity: Estimated annual usage to facilitate production planning.
- Purity Specifications: Any specific impurity profiles that must be avoided.
- Delivery Location: To calculate accurate freight costs.
The inquiry process is streamlined to provide rapid feedback. Within 24 to 48 hours, procurement specialists can generate a formal proforma invoice detailing the final cost, lead time, and payment instructions. This efficiency is critical for maintaining project timelines in drug development.
Conclusion
Securing a stable supply of 3-Bromo-1-phenyl-5-(pyridin-2-yl)pyridin-2-one is vital for the continued production of next-generation therapeutics. By understanding the technical nuances of the synthesis route and leveraging volume discounts, pharmaceutical companies can optimize their operational budgets. Partnering with a reputable source ensures that industrial purity standards are met consistently.
For organizations looking to finalize their supply chain strategy for 2026, early engagement with manufacturers is recommended. This proactive approach guarantees access to high-quality materials and favorable commercial terms, securing a competitive advantage in the global market.