Industrial Purity 2-Chloro-4-Amino-6,7-Dimethoxyquinazoline Coa Specs
- [Synthetic Route] Optimized cyclization pathways ensure minimal isomeric impurities and consistent reaction yields for downstream API synthesis.
- [Logistics] Factory-direct tonnage availability with stable supply chains mitigates procurement risks for long-term production cycles.
- [Documentation] Comprehensive batch-specific testing includes HPLC assays, residual solvent analysis, and full regulatory compliance files.
In the landscape of cardiovascular pharmaceutical manufacturing, the reliability of key intermediates dictates the efficiency of the final Active Pharmaceutical Ingredient (API) production. 2-Chloro-4-amino-6,7-dimethoxyquinazoline, identified by CAS 23680-84-4, serves as a critical Pharmaceutical building block for alpha-1 adrenergic antagonists such as Terazosin, Prazosin, and Doxazosin. For process chemists and procurement officers, securing a supply chain that guarantees industrial purity alongside rigorous documentation is paramount. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier global manufacturer dedicated to delivering this essential quinazoline derivative with the consistency required for commercial-scale drug synthesis.
Optimized Synthesis Routes and Impurity Profiles
From a process chemistry perspective, the manufacturing of this quinazoline derivative typically involves the cyclization of substituted benzonitriles or anthranilic acid derivatives with urea or guanidine sources. The critical quality attribute lies in controlling the formation of regioisomers and unreacted starting materials. Our production facilities utilize refined reaction conditions to maximize yield while minimizing the presence of des-chloro or mono-methoxy impurities that can complicate downstream coupling reactions.
When sourcing high-purity 2-Chloro-6,7-dimethoxyquinazolin-4-amine, buyers should prioritize suppliers who employ robust purification protocols such as recrystallization from polar aprotic solvents. This ensures that the final solid meets the stringent requirements for nucleophilic substitution steps in API synthesis. Our custom synthesis capabilities allow for adjustments in particle size and polymorphic form to suit specific process needs, ensuring optimal solubility and reactivity in subsequent manufacturing stages.
Technical Specifications and Quality Parameters
To facilitate rapid vendor qualification, we adhere to strict internal standards that often exceed general market availability. The following table outlines the typical technical specifications for our commercial grade material. These parameters are verified against every batch to ensure batch-to-batch consistency, a critical factor for regulatory filings.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 23680-84-4 | - |
| Molecular Formula | C10H10ClN3O2 | - |
| Molecular Weight | 239.66 g/mol | - |
| Appearance | White to Off-White Crystalline Powder | Visual |
| Assay (HPLC) | ≥ 98.5% (Typical >99.0%) | Area Normalization |
| Melting Point | 262-268 °C (dec.) | Capillary Method |
| Loss on Drying (LOD) | ≤ 0.5% | Karl Fischer / Oven |
| Residue on Ignition | ≤ 0.1% | Gravimetric |
| Heavy Metals | ≤ 10 ppm | ICP-MS |
Certificate of Analysis Documentation Standards
For regulatory compliance and quality assurance, the COA is more than a specification sheet; it is a legal document verifying the identity and purity of the material. Our documentation package includes detailed chromatograms showing the separation of the main peak from potential impurities, ensuring transparency in the synthesis route outcomes. We provide full traceability from raw material intake to final packaging, supporting audits for REACH and TSCA compliance.
Executive decision-makers must consider the stability of the supply chain when selecting a partner for API intermediate procurement. Market fluctuations often lead to variability in purity levels, with some suppliers offering only 95% purity which may require additional purification steps by the buyer. NINGBO INNO PHARMCHEM CO.,LTD. mitigates this risk by maintaining large-scale production capacity, ensuring that tonnage quantities are available without compromising on the process-scale purity required for GMP environments.
Storage, Safety, and Procurement
Proper handling is essential to maintain the integrity of this chemical. The material should be stored in a cool, dry place, ideally between 2-8°C, in tightly closed containers to prevent moisture uptake, which can affect the Loss on Drying specifications. Safety data indicates the compound is an irritant (GHS07), requiring appropriate personal protective equipment during handling. Our logistics team ensures that all shipments are packaged according to international hazardous material regulations, providing Safety Data Sheets (SDS) with every order.
For organizations seeking to stabilize their supply chain for alpha-blocker production, securing a reliable source for CAS 23680-84-4 is a strategic priority. We invite quality assurance managers and procurement directors to contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote. Partnering with a dedicated manufacturer ensures that your production timelines remain uninterrupted by supply volatility.