4-(Boc-Amino)-1-Butanol Synthonix B50595 Alternative Supplier
Validating MFCD01861334 Cross-Reference Compatibility with Synthonix B50595
In pharmaceutical process development, cross-referencing chemical identifiers is critical for ensuring supply chain continuity. The target compound, 4-(Boc-amino)-1-butanol, is frequently indexed under MFCD01861334 and often sought as a direct functional alternative to Synthonix B50595. Procurement teams must verify that the molecular identity aligns precisely across these catalog numbers to prevent workflow disruptions in downstream synthesis. At NINGBO INNO PHARMCHEM CO.,LTD., we prioritize structural verification to ensure that our 4-(Boc-amino)-1-butanol matches the required stoichiometry and functional group integrity expected from legacy supplier codes.
Validation begins with confirming the CAS Registry Number 75178-87-9. This identifier remains constant regardless of the vendor-specific catalog code. When substituting materials in established protocols, particularly for spermidine analogs or polymer conjugation, the Boc-protected amino alcohol must exhibit identical reactivity profiles. Discrepancies often arise not from the core structure, but from trace impurities or hydration levels that affect molar calculations. Our quality control protocols focus on matching the exact molecular weight and elemental analysis to ensure seamless integration into your existing R&D pipelines without requiring method re-validation.
Technical Specifications and Molecular Identity Verification Protocols
Accurate molecular identity verification relies on multi-method analytical confirmation. The chemical formula C9H19NO3 corresponds to a molecular weight of approximately 189.26 g/mol. However, batch-specific molecular weights may vary slightly due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. For precise molar calculations, especially in millimolar concentrations for biochemical research, relying on the theoretical weight alone is insufficient.
Identity protocols should include Infrared Spectrum (IR) authentication and Nuclear Magnetic Resonance (NMR) profiling. The IR spectrum must match the authentic reference standard, confirming the presence of the carbamate linkage and the primary hydroxyl group. Furthermore, elemental analysis should align with theoretical values: C, 57.12%; H, 10.12%; N, 7.40%; O, 25.36%. Deviations beyond standard analytical error margins often indicate the presence of residual starting materials or degradation products. For detailed physical constants, please refer to the batch-specific COA provided with each shipment.
Essential Purity Grades and Impurity Profiles for Peptide Synthesis Workflows
In peptide synthesis and bioconjugation applications, the purity grade of the Boc-aminobutanol directly influences coupling efficiency and final product quality. Industrial purity grades typically target assay values above 97.5%, but the impurity profile is equally significant. Common impurities include unreacted 4-amino-1-butanol or di-Boc protected species, which can complicate purification steps later in the synthesis route.
From a field engineering perspective, handling this chemical requires attention to its thermal properties. The material exhibits a melting point range of 37°C to 40°C. This narrow range presents a non-standard parameter challenge during winter logistics. If shipped in unheated containers during cold months, the product may crystallize or solidify within the drum. Attempting to dispense solidified material without controlled warming can lead to localized overheating, potentially triggering thermal degradation of the Boc group. We recommend gradual equilibration to room temperature before opening containers to maintain chemical integrity. For more insights on maintaining integrity during storage, review our data on Boc-Protected Amino Alcohol Polymer Conjugation Linker Stability.
Critical COA Parameters: HPLC Assay Limits and Residual Solvent Analysis
The Certificate of Analysis (COA) is the definitive document for verifying batch quality. Key parameters include the assay percentage, typically determined by Gas Chromatography (GC) or High-Performance Liquid Chromatography (HPLC). A minimum assay of 97.5% is standard for research-grade material, but specific projects may require tighter tolerances. Residual solvent analysis is also critical, as remnants of process solvents like dichloromethane or ethyl acetate can interfere with sensitive catalytic reactions.
Below is a comparison of typical technical parameters expected for high-purity intermediates versus standard industrial grades:
| Parameter | Research Grade Specification | Industrial Grade Specification | Test Method |
|---|---|---|---|
| Assay (Purity) | > 98.0% | > 97.5% | GC / HPLC |
| Melting Point | 37°C - 40°C | 35°C - 42°C | DSC / Capillary |
| Appearance | Colorless to Pale Yellow | Colorless to Yellow | Visual |
| Residual Solvents | < 500 ppm Total | < 1000 ppm Total | GC Headspace |
| Water Content | < 0.5% | < 1.0% | Karl Fischer |
Optimizing the synthesis route often involves balancing these purity levels against cost. For guidance on manufacturing processes, consult our technical brief on Optimizing 4-(Boc-Amino)-1-Butanol Synthesis Route Industrial Purity.
Bulk Packaging Configurations and Stability Guarantees for R&D Scale-Up
Scaling from laboratory benchtop to pilot plant requires consistent packaging configurations that ensure stability during transit and storage. Standard packaging options include 25kg fiber drums with polyethylene liners or 210L drums for larger tonnage requirements. The choice of packaging impacts the material's exposure to moisture and oxygen, which are primary drivers of degradation for carbamate intermediates.
Stability guarantees focus on physical containment rather than regulatory certifications. Properly sealed containers protect the hydroxybutyl carbamate from hydrolysis. Upon receipt, materials should be stored in a cool, dry place, ideally under inert gas headspace if long-term storage is anticipated. NINGBO INNO PHARMCHEM CO.,LTD. ensures that all bulk shipments are secured with tamper-evident seals and labeled with batch numbers for full traceability. This allows procurement managers to track specific lots through to final product manufacturing, ensuring compliance with internal quality standards.
Frequently Asked Questions
What is the typical lead time for bulk orders of CAS 75178-87-9?
Lead times vary based on current inventory levels and production schedules. Standard stock items typically ship within 5-7 business days, while custom tonnage orders may require 2-4 weeks for manufacturing and quality testing.
Can you provide a Certificate of Analysis before purchase?
Yes, we can provide a representative COA for recent batches upon request. Please note that the final shipped batch will have its own specific COA reflecting exact test results for that production run.
What solvent is recommended for preparing stock solutions?
Common organic solvents such as DMSO, DMF, or ethanol are suitable. However, due to batch-specific hydration variations, precise solvent volumes should be calculated based on the actual batch molecular weight provided in the documentation.
Is this material suitable for GMP manufacturing?
Our standard grades are intended for R&D and industrial use. For GMP applications, please contact our technical team to discuss specific quality agreements and additional testing protocols required for your process.
Sourcing and Technical Support
Securing a reliable supply of critical intermediates like 4-(Boc-amino)-1-butanol is essential for maintaining project timelines in pharmaceutical and polymer development. By understanding the technical nuances of purity, packaging, and handling, procurement teams can mitigate risks associated with material variability. Our engineering team is available to discuss specific application requirements and provide data-driven support for your synthesis workflows.
Ready to optimize your supply chain? Reach out to our logistics team today for comprehensive specifications and tonnage availability.