Azacitidine: A Breakthrough in Hematologic Cancer Treatment
Understanding the mechanism and benefits of Azacitidine for MDS and AML patients.
Get a Quote & SampleUnderstanding Azacitidine's Core Value
Azacitidine (CAS 320-67-2)
Azacitidine is a critical pharmaceutical ingredient known for its role in treating myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Its therapeutic efficacy stems from its ability to modulate epigenetic mechanisms within cancer cells, offering a new avenue for treatment.
- How does azacitidine work? It primarily functions by inhibiting DNA methyltransferase, leading to hypomethylation of DNA and reactivation of silenced tumor suppressor genes.
- What is the azacitidine mechanism of action? The drug incorporates into DNA and RNA, with its DNA incorporation leading to covalent binding with DNA methyltransferases, thereby blocking their function.
- What are the benefits of azacitidine cancer treatment? It has shown significant clinical benefits in improving hematopoiesis and controlling the progression of hematologic malignancies.
- Where can I find information on azacitidine drugbank? Detailed pharmacological information and research on azacitidine can be found in comprehensive drug databases.
Key Advantages of Azacitidine Therapy
Epigenetic Modulation
Azacitidine's ability to induce DNA hypomethylation is crucial for reactivating tumor suppressor genes, a key aspect of its anti-cancer activity.
Broad Efficacy
The drug is effective in treating both Myelodysplastic Syndromes and Acute Myeloid Leukemia, addressing significant unmet needs in oncology.
Improved Hematopoiesis
Azacitidine can lead to better bone marrow function, helping to alleviate symptoms like anemia and low platelet counts in patients.
Key Applications
Myelodysplastic Syndromes (MDS) Treatment
Azacitidine is a cornerstone therapy for patients with MDS, helping to improve blood counts and quality of life.
Acute Myeloid Leukemia (AML) Management
It is also indicated for AML, particularly in patients who cannot undergo intensive curative treatment, offering a vital therapeutic option.
Research in Leukemia Therapeutics
The study of azacitidine's mechanism provides a foundation for developing new and improved treatments for various leukemias.
Oncology Drug Development
As a leading epigenetic therapy, azacitidine informs ongoing research into novel cancer treatments targeting gene expression.