Calotropin (CAS 1986-70-5): A Potent Cardenolide for Anticancer Research and Development
Discover the cytotoxic power of Calotropin, a natural compound with significant anticancer potential.
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Calotropin
Calotropin is a highly potent cardenolide-type cardiac glycoside with significant cytotoxic and anticancer activities. It acts by inhibiting the Na+/K+-ATPase, disrupting cellular ion balance, and inducing apoptosis, making it a valuable agent in preclinical cancer research.
- Research Chemical Calotropin CAS 1986-70-5: Ideal for studies investigating anticancer mechanisms and drug discovery.
- Calotropin Anticancer Mechanism: Its ability to induce apoptosis and cell cycle arrest highlights its therapeutic potential.
- Calotropis procera Cytotoxic Compounds: Explore its origin from natural sources and their medicinal applications.
- Cardenolide Na+/K+-ATPase Inhibition: Understand its mode of action, crucial for understanding its effects on cardiac and cancer cells.
Advantages of Calotropin
Potent Cytotoxicity
Calotropin exhibits potent in vitro cytotoxicity against various cancer cell lines, offering a strong starting point for novel therapeutic development.
Apoptosis Induction
This cardenolide effectively triggers apoptosis in cancer cells, a key mechanism in effective cancer treatments.
Natural Origin and Research Value
Isolated from natural sources, Calotropin provides valuable insights into plant-derived bioactive compounds for pharmaceutical research.
Key Applications
Anticancer Research
Calotropin is extensively studied for its anti-tumor impacts, particularly against breast, colon, and lung cancers, leveraging its cytotoxic properties.
Biochemical Studies
Its role in inhibiting Na+/K+-ATPase makes it crucial for understanding cellular ion transport and its physiological consequences.
Drug Discovery
As a promising anticancer agent, Calotropin serves as a lead compound for developing new pharmaceuticals targeting specific cancer signaling pathways.
Phytochemical Investigation
Investigating its presence in Calotropis species contributes to the broader understanding of medicinal plants and their bioactive compounds.