Epacadostat (INCB024360): A Potent IDO1 Inhibitor for Cancer Immunotherapy
Discover the science behind Epacadostat, a groundbreaking IDO1 inhibitor revolutionizing cancer immunotherapy by restoring the immune system's ability to fight tumors.
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Epacadostat
As a leading supplier of high-quality pharmaceutical intermediates from China, we offer Epacadostat (INCB024360), a potent and selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. This small molecule is designed to enhance the body's immune response against cancer by targeting the IDO1 enzyme, which tumors exploit to evade immune surveillance. Our commitment to purity and quality ensures that Epacadostat is a reliable component for your research and development needs in the field of cancer immunotherapy.
- Mechanism of Action: Epacadostat works by inhibiting IDO1, an enzyme that metabolizes tryptophan and leads to immune suppression. By blocking this pathway, it helps restore the function of critical immune cells, contributing to a more robust anti-tumor response.
- Therapeutic Potential: Research indicates that Epacadostat can promote T-cell and natural killer (NK)-cell activation, increase interferon-gamma production, and reduce the presence of tumor-associated regulatory T cells (Tregs).
- Research Applications: This compound is invaluable for exploring immune modulation strategies and understanding the intricacies of tumor microenvironment modulation in preclinical cancer models.
- Quality Assurance: We provide Epacadostat with high purity, backed by comprehensive documentation, ensuring reliability for demanding research applications in novel cancer therapeutics research and pharmaceutical intermediate synthesis.
Advantages Offered by Epacadostat
Enhanced Immune Response
Epacadostat helps overcome tumor-induced immunosuppression, allowing your immune system to more effectively target cancer cells, a key aspect of cancer immunotherapy.
Targeted Mechanism
Its selective inhibition of IDO1 provides a precise mechanism for intervention in immune modulation pathways, crucial for developing effective cancer treatments.
Preclinical Validation
Backed by extensive preclinical data, Epacadostat serves as a vital tool for researchers investigating novel cancer therapeutics research and validating small molecule immuno-oncology approaches.
Key Applications
Oncology Drug Development
Epacadostat is instrumental in the development of new antineoplastic agents and understanding cancer immune evasion IDO1 mechanisms.
Immunotherapy Research
Explore the potential of combining Epacadostat with other immunotherapies to achieve synergistic effects in treating various cancers.
Pharmacological Studies
Utilize Epacadostat in in vitro and in vivo studies to investigate its impact on immune cell proliferation and cytokine production, aiding in restoring immune response in tumors.
Biochemical Assays
Its well-defined inhibitory profile makes it ideal for use in biochemical assays to screen for other IDO1 modulators or study enzyme kinetics.