High Purity Gimeracil CAS 103766-25-2: An Advanced Antitumor Agent
Enhancing chemotherapy efficacy through potent DPD inhibition for improved cancer treatment outcomes.
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Gimeracil
Gimeracil (CAS 103766-25-2) is a critical pharmaceutical active ingredient renowned for its potent antitumor activity. Its primary mechanism involves inhibiting dihydropyrimidine dehydrogenase (DPD), a key enzyme responsible for the degradation of 5-fluorouracil (5-FU) and related fluoropyrimidines. By competitively and reversibly inhibiting DPD, Gimeracil significantly enhances the plasma concentration and prolongs the half-life of these chemotherapeutic agents. This action leads to more sustained and effective cytotoxic effects on cancer cells, thereby improving overall treatment efficacy. The ability to achieve higher therapeutic levels of 5-FU with Gimeracil also aids in mitigating some of the severe side effects often associated with higher doses of these drugs, making it a valuable component in complex cancer treatment regimens.
- Discover the precise mechanism of Gimeracil in enhancing chemotherapy efficacy by understanding its role as a DPD inhibitor.
- Learn how Gimeracil aids in the antitumor activity for fluoropyrimidines, improving treatment outcomes.
- Explore how Gimeracil contributes to reducing the degradation of 5-FU, ensuring prolonged therapeutic action.
- Understand the significance of Gimeracil for cancer treatment by stabilizing drug concentrations and improving patient tolerance.
Key Advantages
Enhanced Therapeutic Potency
Gimeracil acts as a crucial DPD inhibitor, significantly boosting the therapeutic efficacy of commonly used fluoropyrimidine anticancer drugs by ensuring higher and more sustained drug levels at the tumor site.
Improved Pharmacokinetics
By blocking the degradation pathways of agents like 5-FU, Gimeracil optimizes their pharmacokinetic profiles, leading to improved bioavailability and longer persistence in the bloodstream, critical for effective cancer treatment.
Side Effect Management
The stabilization of plasma drug concentrations achieved with Gimeracil can help in managing the adverse effects associated with chemotherapy, contributing to better patient tolerability and compliance.
Key Applications
Antitumor Therapies
Gimeracil is vital in augmenting the effectiveness of various antitumor treatments, particularly those relying on fluoropyrimidine agents.
Chemotherapy Enhancement
Its primary role is to enhance the overall efficacy of chemotherapy regimens by preventing the premature breakdown of active drug compounds, thereby supporting advanced cancer treatment strategies.
Pharmaceutical Research
As a key component in combination therapies, Gimeracil is instrumental in drug discovery and research, offering insights into optimized drug delivery and enhanced patient outcomes.
Cancer Treatment Regimens
Gimeracil is a critical component in specific combination drug formulations used to combat various types of cancer, offering a more potent and potentially better-tolerated treatment option.