Lesinurad: Enhancing Gout Treatment with Advanced Pharmaceutical Chemistry
Discover the key properties and therapeutic applications of Lesinurad, a vital component in managing hyperuricemia and gout.
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Urate Transporter Inhibitor
Lesinurad (CAS 878672-00-5) is a pharmaceutical active ingredient designed to target hyperuricemia associated with gout. By inhibiting specific urate transporters in the kidneys, it significantly enhances the excretion of uric acid, thereby lowering blood uric acid levels.
- Mechanism of Action: As a selective inhibitor of uric acid reabsorption, Lesinurad works by blocking URAT1 and OAT4 transporters in the kidneys, a key aspect of its gout treatment efficacy.
- Therapeutic Combination: This compound is intended for use in combination with xanthine oxidase inhibitors, such as allopurinol, to achieve optimal serum uric acid targets in patients with hyperuricemia management.
- Chemical Purity and Form: Supplied typically as a white to off-white crystalline powder with an assay exceeding 99%, ensuring high quality for pharmaceutical applications and buy Lesinurad online.
- Clinical Significance: Lesinurad plays a crucial role in managing gout by directly addressing elevated uric acid levels, offering a therapeutic option for individuals not adequately controlled by monotherapy.
Key Advantages of Lesinurad
Targeted Uric Acid Reduction
Lesinurad effectively lowers serum uric acid levels by promoting its excretion, a critical step in the Lesinurad uses for gout.
Synergistic Therapeutic Effects
When combined with xanthine oxidase inhibitors, Lesinurad offers enhanced efficacy for patients struggling to reach target uric acid levels, optimizing gout management.
High Purity and Reliability
Ensuring a purity of over 99%, Lesinurad from reputable Lesinurad suppliers provides reliability for critical pharmaceutical formulations.
Key Applications
Gout Therapy
Lesinurad is a crucial pharmaceutical intermediate for the development of advanced treatments for gout, addressing the underlying cause of the condition.
Hyperuricemia Control
It serves as an active pharmaceutical ingredient (API) to manage elevated uric acid levels in the blood, vital for preventing gout flares.
Pharmaceutical Research & Development
Used in R&D to explore new therapeutic strategies and combinations for metabolic disorders related to uric acid, supporting Lesinurad drug interactions studies.
Combination Drug Formulations
Essential component in creating combination therapies that offer a more comprehensive approach to managing chronic gout conditions.
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