Lumefantrine: A Comprehensive Guide to its Properties, Applications, and Benefits
Discover the critical role of Lumefantrine in combating malaria with detailed insights into its properties and applications.
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Lumefantrine
Lumefantrine, also known as benflumetol, is a vital antimalarial pharmaceutical intermediate, primarily recognized for its efficacy when used in combination with artemether. This powerful combination is instrumental in clearing residual parasites that may remain after initial treatment, significantly contributing to malaria eradication efforts. Its high purity, often exceeding 99%, and stable yellow powder form make it a reliable component in pharmaceutical formulations.
- Understanding the lumefantrine mechanism of action reveals its dual approach: inhibiting beta-hematin formation and interfering with nucleic acid and protein synthesis within the malaria parasite.
- The lumefantrine half-life is significantly longer than artemether's, ensuring prolonged therapeutic effect and reducing the risk of parasite relapse.
- Sourcing high-purity lumefantrine powder with 99% purity is essential for effective and safe antimalarial treatments.
- Researching the best lumefantrine CAS 82186-77-4 suppliers ensures access to quality-assured pharmaceutical ingredients for advanced research and drug development.
Advantages Offered by Lumefantrine
Enhanced Parasite Clearance
Lumefantrine's prolonged half-life complements artemether, ensuring thorough eradication of malaria parasites and preventing the development of drug resistance.
High Purity and Stability
With a purity typically exceeding 99%, lumefantrine powder provides a stable and reliable active pharmaceutical ingredient for consistent therapeutic outcomes.
Critical Role in Combination Therapy
As a key component in widely used antimalarial combinations, lumefantrine is indispensable for effective malaria treatment protocols globally.
Key Applications
Malaria Treatment
Lumefantrine is a cornerstone in the treatment of uncomplicated Plasmodium falciparum malaria, particularly when combined with artemether, addressing a significant global health challenge.
Pharmaceutical Intermediate
Its high quality and specific chemical properties make it a valuable intermediate in the synthesis of various pharmaceutical compounds and research chemicals.
Drug Efficacy Research
Researchers utilize lumefantrine to study drug interactions, resistance mechanisms, and to develop novel antimalarial therapies, contributing to ongoing advancements in medicinal chemistry.
Global Health Initiatives
The availability of lumefantrine supports international efforts to control and eliminate malaria, making it a critical compound for public health programs worldwide.