Mildronate CAS 76144-81-5: Understanding its Pharmaceutical Applications and Cardioprotective Benefits
Explore the cardioprotective and neuroprotective benefits of Mildronate, a key pharmaceutical intermediate.
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Mildronate
Mildronate (CAS 76144-81-5) is a novel cardioprotective agent that acts on mitochondria at the cellular level to improve myocardial energy metabolism. It is known to inhibit carnitine biosynthesis, which directly impacts the transport of carnitine-dependent fatty acids in mitochondria, thereby optimizing energy supply to tissues during ischemic conditions.
- Explore the Mildronate mechanism of action: This pharmaceutical intermediate inhibits carnitine biosynthesis, a key step in managing cellular energy.
- Understand Meldonium cardioprotective drug benefits: Mildronate offers significant protective effects on the myocardium, aiding in recovery from various cardiac events.
- Discover Mildronate pharmaceutical applications: Its uses extend beyond cardiovascular health, including potential benefits for neurological disorders and alcohol withdrawal symptoms.
- Learn about Mildronate as an athlete performance enhancer: While controversial and banned by some sporting bodies, its role in energy metabolism has led to discussions about athletic performance.
Advantages of Mildronate
Enhanced Cellular Energy Metabolism
By inhibiting carnitine-dependent fatty acid oxidation, Mildronate promotes glucose oxidation, providing a more efficient energy source for cells, especially under stress. This is crucial for understanding how to inhibit carnitine biosynthesis effectively.
Cardiovascular Support
Mildronate is recognized for its role in treating various cardiovascular diseases, offering a protective effect on the heart without significantly altering hemodynamic parameters. Its application in stable angina and chronic heart failure is well-documented.
Neuroprotective Properties
Studies suggest that Mildronate can improve cerebral circulation disorders and central nervous system functions, indicating its value as a neuroprotective agent for brain health.
Key Applications
Cardiovascular Diseases
Used in the treatment of conditions like stable angina, chronic heart failure, and cardiomyopathy to improve myocardial energy metabolism and protect heart tissue.
Ischemic Conditions
Effective in managing acute and chronic ischemic attacks by ensuring better energy supply to oxygen-deprived tissues.
Neurological Support
Beneficial for brain circulation disorders and injuries, acting as a neuroprotective agent for cognitive health.
Alcohol Withdrawal Symptoms
Can be used to alleviate the functional damage to the nervous system in patients experiencing chronic alcoholism withdrawal.