Enrofloxacin Hydrochloride: Enhancing Antibacterial Efficacy and Solubility for Veterinary Applications
Discover the next generation of veterinary antibiotics with enhanced solubility and potent antibacterial action.
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Enrofloxacin Hydrochloride
Enrofloxacin Hydrochloride is a potent synthetic fluoroquinolone antibiotic widely used in veterinary medicine. While effective, its low water solubility has historically limited its bioavailability and formulation flexibility. This research focuses on developing novel molecular salts of Enrofloxacin Hydrochloride using isomeric pyridine-2,n-dicarboxylic acids, aiming to overcome these limitations.
- Leveraging Crystal Engineering for Enhanced Drug Solubility: Our innovative approach utilizes crystal engineering principles to create new crystalline forms of Enrofloxacin Hydrochloride with significantly improved water solubility, addressing a key challenge in its application.
- Significantly Improved Water Solubility for Better Bioavailability: The synthesized salts exhibit substantial increases in water solubility, with some showing up to a 115-fold enhancement compared to the parent drug, which directly translates to improved bioavailability for veterinary patients.
- Retaining Potent Antibacterial Activity: Biological studies confirm that these novel salts maintain, and in some cases enhance, the broad-spectrum antibacterial activity of Enrofloxacin Hydrochloride against critical Gram-positive and Gram-negative pathogens.
- Demonstrating Safety and Efficacy: Cytotoxicity tests have shown that the new Enrofloxacin Hydrochloride salts exhibit negligible hemolytic activity, indicating a favorable safety profile for veterinary use.
Key Advantages
Enhanced Solubility
Our Enrofloxacin Hydrochloride salts demonstrate superior water solubility, ensuring better absorption and efficacy in various veterinary treatments.
Potent Antibacterial Action
Experience robust and broad-spectrum antibacterial activity against a wide range of pathogens, essential for combating animal infections.
Improved Bioavailability
The enhanced solubility directly contributes to improved bioavailability, allowing for more effective drug delivery and potentially lower required dosages.
Key Applications
Livestock Health Management
Combat bacterial infections in cattle, swine, and poultry, ensuring the health and productivity of farm animals.
Aquatic Disease Control
Address bacterial and mycoplasmal infections in fish, crucial for aquaculture operations.
Companion Animal Care
Treat bacterial infections in dogs and cats, supporting the health of pets with effective antibacterial solutions.
Pharmaceutical Intermediate Development
Utilize these novel salts as advanced pharmaceutical intermediates for the development of next-generation veterinary drugs.
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