NINGBO INNO PHARMCHEM CO.,LTD. is proud to feature Aztreonam (CAS 78110-38-0), a synthetic antibiotic whose primary mode of action offers significant insights into bacterial biology. Its ability to inhibit bacterial cell wall synthesis is a key aspect that researchers leverage to understand bacterial structural integrity and develop new therapeutic approaches.

The bacterial cell wall is a critical protective layer that maintains the shape and structural integrity of bacteria, preventing them from bursting due to osmotic pressure. Aztreonam targets this essential structure by interfering with the final stages of peptidoglycan synthesis. Specifically, it binds to Penicillin-Binding Protein 3 (PBP3), a transpeptidase enzyme responsible for cross-linking peptidoglycan chains. This cross-linking is vital for creating a strong and resilient cell wall.

When Aztreonam binds to PBP3, it prevents the formation of these crucial cross-links. The resulting weakening of the cell wall makes the bacteria susceptible to lysis, particularly in the hypotonic environments where many infections occur. This precise mechanism of inhibition is a focal point for researchers studying bacterial survival mechanisms and seeking to develop novel antibacterial agents that exploit this vulnerability.

The study of Aztreonam’s effect on cell wall synthesis is particularly relevant for Gram-negative bacteria, where PBP3 plays a more dominant role in maintaining shape during cell division. Researchers often purchase Aztreonam from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. to conduct detailed in vitro experiments. The price of Aztreonam reflects its importance in elucidating these fundamental biological processes.

By understanding how Aztreonam inhibits bacterial cell wall synthesis, scientists can develop more targeted and effective treatments, and also explore new ways to disarm bacterial defenses. This makes Aztreonam an indispensable tool in the ongoing fight against infectious diseases.