NINGBO INNO PHARMCHEM CO.,LTD. is a key provider of essential pharmaceutical components, including Calcium Folinate (CAS 6035-45-6), a compound with critical roles in both advanced cancer therapies and the management of certain anemias. Its unique biochemical properties make it an indispensable tool for clinicians worldwide.

In oncology, the utility of Calcium Folinate is most notably seen in its combination with fluorouracil (5-FU). The synergy in calcium folinate and fluorouracil chemotherapy is a well-established strategy to enhance treatment efficacy. By increasing the intracellular pool of active folates, Calcium Folinate stabilizes the interaction between 5-FU's active metabolite and thymidylate synthase, an enzyme critical for DNA synthesis. This interaction leads to a more robust inhibition of cancer cell proliferation. For entities looking to buy Calcium Folinate raw material, NINGBO INNO PHARMCHEM CO.,LTD. ensures a supply of consistent quality.

A particularly life-saving application is calcium folinate rescue therapy. High-dose methotrexate (MTX) is a powerful chemotherapeutic agent, but its toxicity to healthy cells necessitates protective measures. Calcium Folinate acts as a rescue agent, bypassing the MTX-induced blockade of dihydrofolate reductase and replenishing the body's supply of essential reduced folates. This protection is crucial for preventing severe side effects like myelosuppression and mucositis, thereby allowing patients to tolerate aggressive cancer treatments.

Furthermore, Calcium Folinate plays a significant role in hematology, particularly in treating specific types of anemia. It is indicated for megaloblastic anemia arising from folate antagonists that disrupt folate metabolism. This makes it essential for patients whose conditions or treatments interfere with normal folate utilization. The management of calcium folinate for megaloblastic anemia requires reliable access to pure compounds, such as the high purity calcium folinate powder supplied by NINGBO INNO PHARMCHEM CO.,LTD.

NINGBO INNO PHARMCHEM CO.,LTD.'s commitment to providing high-quality pharmaceutical intermediates like Calcium Folinate directly supports advancements in patient care. Their role in the supply chain ensures that critical therapeutic agents are available to those who need them most, underpinning successful treatment protocols in oncology and hematology.