Monobenzone powder is a sophisticated chemical compound valued for its potent depigmenting capabilities. For professionals in the pharmaceutical and cosmetic sectors, understanding its precise chemical properties and specifications is fundamental to its effective and safe utilization. This overview details the critical attributes of high-purity Monobenzone powder.

Chemical Identity and Structure:

Monobenzone is chemically known as 4-Benzyloxyphenol, or hydroquinone monobenzyl ether. Its molecular formula is C13H12O2, and it is identified by the CAS number 103-16-2. This chemical structure underpins its biological activity, particularly its role as a tyrosinase inhibitor, which is central to melanin synthesis regulation.

Appearance and Physical State:

High-purity Monobenzone powder typically presents as a white to off-white crystalline powder. The consistent physical form is indicative of a well-controlled manufacturing process, ensuring uniformity in batch-to-batch production. This characteristic appearance is a primary visual indicator of quality for buyers.

Purity and Assay:

The efficacy and safety of Monobenzone are directly correlated with its purity. Pharmaceutical-grade Monobenzone, often designated as USP grade, should exhibit a minimum purity of 99%. Assays conducted using methods like High-Performance Liquid Chromatography (HPLC) confirm the concentration of the active compound and the absence of significant impurities. Buyers should always verify the assay results and purity specifications provided by the manufacturer.

Solubility Characteristics:

Understanding the solubility of Monobenzone is crucial for formulation development. It is generally described as slightly soluble in alcohol, chloroform, and ether, while being practically insoluble in water. This solubility profile influences the choice of solvents used in preparing topical solutions or incorporating it into various cosmetic and pharmaceutical bases.

Key Specifications for Buyers:

  • CAS Number: 103-16-2
  • Molecular Formula: C13H12O2
  • Molecular Weight: 200.23 g/mol
  • Appearance: White crystalline powder
  • Purity (Assay): ≥99% (USP Grade)
  • Melting Point: Typically in the range of 110-113 °C
  • Solubility: Soluble in alcohol, ether; insoluble in water
  • Certifications: GMP, ISO are highly desirable indicators of quality.

Quality Assurance and Sourcing:

When sourcing Monobenzone powder, buyers must prioritize manufacturers who provide comprehensive Certificates of Analysis (CoA) detailing these specifications. A commitment to quality, evidenced by certifications and transparent testing procedures, ensures that the procured Monobenzone powder will perform as expected in demanding applications. Reliable suppliers also ensure safe delivery and competitive pricing, making the procurement process efficient and trustworthy.