While both Dydrogesterone and natural Progesterone are progestogens, they possess distinct pharmacological profiles and therapeutic applications. Understanding these differences is essential for healthcare professionals and patients when choosing the most appropriate treatment.

Natural progesterone is a naturally occurring hormone produced by the ovaries. It plays a vital role in the menstrual cycle, pregnancy, and embryo implantation. However, its oral bioavailability is relatively low, and it can be metabolized into sedative neurosteroids, potentially causing drowsiness. Dydrogesterone, on the other hand, is a synthetic progestogen. It was developed to overcome some of the limitations of natural progesterone, particularly its oral bioavailability and metabolic stability. Dydrogesterone acts directly on the uterus and does not significantly inhibit ovulation or affect body temperature, unlike some other progestins. It also lacks the sedative properties associated with progesterone's metabolites.

In terms of therapeutic use, both are employed for progesterone deficiency symptoms. However, dydrogesterone is often preferred for luteal phase support in ART due to its oral administration and consistent efficacy. It is also considered a gentler option for women desiring pregnancy while undergoing treatment for conditions like endometriosis. While natural progesterone is also used in pregnancy support, dydrogesterone's unique properties, such as its non-thermogenic and non-ovulation-inhibiting effects at therapeutic doses, set it apart. For individuals seeking to purchase high-quality dydrogesterone, exploring options from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is advisable.