Equine Protozoal Myeloencephalitis (EPM) is a devastating neurological disease affecting horses, primarily caused by the protozoan parasite Sarcocystis neurona. This condition leads to a range of neurological signs, from ataxia and incoordination to paralysis, significantly impacting a horse's athletic performance and overall well-being. The parasite is transmitted through the feces of infected opossums, and horses become infected by ingesting contaminated feed, water, or pasture. Early and accurate diagnosis is crucial, as prompt treatment can significantly improve the prognosis.

The treatment of EPM has evolved considerably over the years. Initially, treatments focused on pyrimethamine-sulfonamide combinations. However, current therapeutic strategies often include medications like diclazuril, which has shown considerable efficacy in managing EPM. Diclazuril is believed to work by inhibiting merozoite production, a critical step in the parasite's life cycle within the horse. Furthermore, research indicates that diclazuril can cross the blood-brain barrier, reaching therapeutic concentrations in the cerebrospinal fluid necessary to combat the infection effectively.

A key aspect of successful EPM treatment with diclazuril involves careful administration and adherence to prescribed protocols. For instance, treatments for EPM in horses with diclazuril often involve daily administration for an extended period, typically 28 days. The recommended dosage is usually 1 mg/kg of body weight, often given as a top-dress on the horse's feed. This method ensures consistent intake and absorption. It's important to follow the specific diclazuril dosage for horses as recommended by a veterinarian.

NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity diclazuril, serving as a vital resource for veterinarians and horse owners seeking effective EPM solutions. Our commitment as a diclazuril raw material supplier ensures that the active pharmaceutical ingredient is of the highest quality, contributing to the success of EPM treatment regimens. By partnering with us, you gain access to a reliable source for this critical medication, supporting the health and recovery of horses affected by EPM.