Effective management of hypertension and ADHD relies on precise dosing and appropriate administration of medications like Guanfacine HCl. As a supplier of high-quality Guanfacine HCl API, Ningbo Inno Pharmchem Co., Ltd. recognizes the importance of detailed information for healthcare professionals. This guide outlines key considerations for dosage and administration.

For the treatment of hypertension in adults and adolescents 12 years and older, the initial dosage of Guanfacine HCl is typically 1 mg taken once daily, preferably at bedtime. This bedtime administration helps mitigate potential daytime drowsiness. If a satisfactory response is not achieved after 3-4 weeks, the dosage may be increased to 2 mg daily. While higher doses have been used, dosages exceeding 3 mg daily are generally associated with a significant increase in adverse effects. It is crucial to monitor blood pressure regularly and adjust dosage as needed. For patients with renal impairment, lower doses at the beginning of therapy are recommended.

In the management of ADHD, the extended-release formulation of Guanfacine HCl is commonly prescribed. Dosing for ADHD in children and adolescents aged 6 years and older typically starts at 1 mg once daily. Dosage adjustments should be made slowly, often in increments of 1 mg per week, based on efficacy and tolerability, with a maximum recommended daily dose typically not exceeding 4 mg. It is vital to ensure the extended-release tablets are swallowed whole, without crushing, chewing, or breaking them, to maintain the intended release profile. Administration should not be with high-fat meals, as this can affect drug absorption.

When discontinuing Guanfacine HCl, whether for hypertension or ADHD, it is imperative to taper the dose gradually to avoid withdrawal symptoms such as rebound hypertension. Healthcare providers should instruct patients on the proper tapering schedule. The pharmacokinetics of Guanfacine HCl suggest a half-life of around 17 hours, allowing for once-daily dosing. However, individual responses can vary, necessitating personalized treatment plans. Ningbo Inno Pharmchem Co., Ltd. ensures the consistent quality of our Guanfacine HCl API, providing a reliable foundation for pharmaceutical formulations designed for accurate dosing and controlled release. Consulting prescribing information and patient-specific factors is key to successful Guanfacine HCl therapy.