Indomethacin, while highly effective in managing pain and inflammation, is a potent medication that necessitates a thorough understanding of its potential side effects and drug interactions. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes that responsible use, guided by healthcare professionals, is crucial for patient safety.

Common side effects associated with Indomethacin often include gastrointestinal issues such as upset stomach, nausea, indigestion, diarrhea, and constipation. Headaches and dizziness are also frequently reported. While these are typically manageable, persistent or severe symptoms warrant medical attention. More serious, though less common, side effects demand immediate medical intervention. These can include signs of gastrointestinal bleeding (such as black, tarry stools or vomiting blood), severe stomach pain, allergic reactions (rash, itching, difficulty breathing, swelling), cardiovascular events (chest pain, shortness of breath, stroke symptoms), liver damage (jaundice, dark urine, abdominal pain), and kidney problems (decreased urination, swelling).

Drug interactions are another critical aspect to consider when using Indomethacin. Its concomitant use with other NSAIDs, including aspirin, can increase the risk of gastrointestinal bleeding and ulcers. Anticoagulants (like warfarin) and antiplatelet agents (like clopidogrel) can have their effects amplified, raising the risk of serious bleeding. Indomethacin can also interact with certain blood pressure medications, diuretics, lithium, and methotrexate, potentially altering their efficacy or increasing toxicity. For instance, it may reduce the effectiveness of some blood pressure medications and increase the risk of kidney damage when combined with ACE inhibitors or ARBs.

It is imperative for patients to disclose their complete medical history and all medications, including over-the-counter drugs and herbal supplements, to their healthcare provider before starting Indomethacin. This comprehensive understanding allows for a personalized risk assessment and helps in selecting the most appropriate treatment plan. NINGBO INNO PHARMCHEM CO.,LTD. strongly advocates for open communication with healthcare providers to ensure the safe and effective utilization of Indomethacin in pain relief and inflammation management.