Ivacaftor (CAS 873054-44-5) is a groundbreaking pharmaceutical compound that has revolutionized the treatment of cystic fibrosis (CF) by acting as a potent CFTR potentiator. Its precise chemical properties and mechanism of action make it an invaluable tool in both clinical treatment and ongoing scientific research. NINGBO INNO PHARMCHEM CO.,LTD. is a leading supplier of high-quality Ivacaftor, supporting its widespread use in the pharmaceutical and research sectors.

Understanding Ivacaftor's Pharmaceutical Profile

Ivacaftor is characterized by its specific chemical structure, C24H28N2O3, with a molecular weight of 392.49 g/mol. It typically presents as a white to off-white solid powder, indicating a high degree of purity often exceeding 98% by HPLC. This purity is critical for its application as an Active Pharmaceutical Ingredient (API). Ivacaftor exhibits good solubility in organic solvents like DMSO, facilitating its use in various laboratory assays and formulations. Proper storage, usually at -20°C, is recommended to maintain its stability and efficacy. These pharmaceutical properties are meticulously controlled by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. to ensure product reliability.

The Science of CFTR Potentiation by Ivacaftor

The core of Ivacaftor's therapeutic value lies in its function as a CFTR potentiator. It targets the CFTR protein, which is often defective in patients with cystic fibrosis due to various genetic mutations. For mutations like G551D, where the CFTR protein is present at the cell surface but its ion channel gate is frequently closed, Ivacaftor intervenes. It binds to the protein and increases the probability of the channel opening, thereby restoring the flow of chloride ions across cell membranes. This action helps to normalize mucus viscosity and clearance, alleviating key symptoms of CF. The development of Ivacaftor has been a pivotal moment, shifting treatment from symptom management to addressing the underlying molecular defect.

Research Applications and Sourcing Ivacaftor

Beyond its direct therapeutic use, Ivacaftor is an essential research chemical. Scientists utilize it in studies investigating CFTR channel function, exploring new mutations, and developing novel CFTR modulator therapies. Its predictable action makes it a valuable tool for validating experimental models and screening new drug candidates. For researchers and pharmaceutical developers looking to buy Ivacaftor, sourcing from reputable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is paramount. We ensure that our Ivacaftor meets the necessary specifications for experimental reproducibility and safety. Our commitment to quality and a robust supply chain makes us a trusted partner for all Ivacaftor needs.

The Impact on Patient Lives

The availability of Ivacaftor has profoundly impacted the lives of many individuals with cystic fibrosis, offering them a chance to manage their condition more effectively and improve their overall health. NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to this advancement by ensuring the reliable supply of this critical pharmaceutical compound.