For formulators and researchers working with local anesthetics, understanding the nuances between different forms of a compound is crucial for achieving optimal results. NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-quality Lidocaine Hydrochloride powder, but we also recognize the importance of differentiating it from Lidocaine base. This knowledge is vital for selecting the correct ingredient for specific applications.

The fundamental difference lies in their chemical structure and, consequently, their physical properties. Lidocaine Hydrochloride (CAS 73-78-9) is the salt form of Lidocaine. It is formed by reacting Lidocaine base with hydrochloric acid. This salt formation significantly impacts its solubility. While Lidocaine base is practically insoluble in water, Lidocaine Hydrochloride powder is highly soluble in water. This high water solubility makes it the preferred choice for aqueous formulations, such as injectable solutions, topical gels, and oral rinses.

The pH of aqueous solutions also differs. Solutions of Lidocaine Hydrochloride are typically acidic, often falling within the pH range of 4 to 5. This is due to the nature of the hydrochloride salt. On the other hand, Lidocaine base, being an amine, is alkaline. The pKa of Lidocaine is approximately 7.8. This value is significant because it indicates that at a pH above 7.8, Lidocaine will exist predominantly in its non-ionized (base) form, and at a pH below 7.8, it will be mostly ionized (salt) form. This characteristic is particularly relevant when considering how the drug interacts with biological membranes.

When considering topical applications, the form of Lidocaine chosen can influence the onset and duration of action. For applications where rapid onset is desired and the target site is a mucous membrane or broken skin, Lidocaine Hydrochloride is often favored due to its quick absorption. For intact skin, where penetration of the stratum corneum is a barrier, the non-ionized Lidocaine base, being more lipophilic, may sometimes offer better penetration, especially when formulated in anhydrous bases. However, many topical formulations still utilize Lidocaine Hydrochloride due to ease of formulation and stability.

NINGBO INNO PHARMCHEM CO.,LTD. supplies Lidocaine powder USP/BP/EP, ensuring formulators have access to the highest purity ingredients. Whether you require the water-soluble Lidocaine Hydrochloride for liquid preparations or are exploring applications for Lidocaine base, our comprehensive product range and technical support can assist you. We understand the intricacies of Lidocaine powder medical applications and Lidocaine powder cosmetic use, and are committed to providing the right product for your specific needs.

In conclusion, the choice between Lidocaine Hydrochloride and Lidocaine base hinges on the intended formulation and application. Lidocaine Hydrochloride's superior water solubility makes it a versatile ingredient for many aqueous-based preparations, while its salt form influences its behavior in different pH environments. NINGBO INNO PHARMCHEM CO.,LTD. is your trusted partner for sourcing pure Lidocaine Hydrochloride powder, backed by expertise and a commitment to quality.