Obesity prevalence is rising globally, but its characteristics and optimal management strategies can vary significantly across different ethnicities. Mazdutide, a cutting-edge GLP-1R/GCGR dual agonist, has shown particularly compelling results in studies primarily involving Chinese adults, offering valuable insights for precision weight management in Asian populations.


Recognizing that Asian populations often have different body fat distribution and cardiovascular risk profiles at lower BMI levels compared to Western populations, the Chinese criteria for overweight and obesity (BMI ≥ 24 kg/m2 and ≥ 28 kg/m2, respectively) are distinct. Mazdutide’s clinical trials, such as GLORY-1, were specifically designed with these criteria in mind, enrolling a predominantly Chinese cohort. The results from these trials confirmed robust and clinically significant body weight reductions across various doses, demonstrating its applicability and effectiveness within this demographic.


Beyond substantial weight loss, Mazdutide also delivered significant improvements in key cardiometabolic risk factors prevalent in Asian adults, including reductions in waist circumference, blood pressure, lipid levels, and particularly, liver fat content. This comprehensive metabolic benefit addresses the interconnected health challenges often faced by individuals in these populations. The safety profile observed was consistent with previous studies, with mild and transient gastrointestinal side effects being the most common, underscoring its tolerability for long-term use.


The focused research on Chinese populations provides crucial evidence for how GLP-1-based pharmacotherapy can effectively support weight management for Asian adults who may not achieve desired weight loss through lifestyle interventions alone. This targeted approach is vital for developing precision medicine strategies that cater to specific ethnic health needs. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated Mazdutide supplier, ensuring that high-quality active pharmaceutical ingredients are available to support global health initiatives, including focused research into Mazdutide for Chinese patients and other specific populations. Our commitment to excellence helps facilitate the availability of innovative treatments to those who need them most.