Optimizing Oral Dosage Forms: The Role of Sodium Starch Glycolate as a Tablet Disintegrant
The development of effective oral dosage forms, such as tablets and capsules, relies heavily on the performance of excipients. NINGBO INNO PHARMCHEM CO.,LTD. highlights the pivotal role of Sodium Starch Glycolate (SSG) as a superior tablet disintegrant. Its unique ability to promote rapid disintegration is key to optimizing the release and absorption of active pharmaceutical ingredients (APIs).
Sodium Starch Glycolate, with its CAS number 9063-38-1, is a cross-linked derivative of starch that exhibits remarkable swelling characteristics when exposed to water. This property is fundamental to its function as a disintegrant. When a tablet containing SSG comes into contact with gastrointestinal fluids, the excipient rapidly absorbs water, swells significantly, and exerts internal pressure. This pressure causes the tablet to break apart into smaller fragments, a process crucial for ensuring that the API is readily available for absorption into the bloodstream. This mechanism directly contributes to the drug absorption efficiency of the formulation.
As a leading pharmaceutical excipient for tablets, SSG offers distinct advantages. Its efficacy as a rapid disintegration agent is consistently demonstrated across various formulations. Unlike some other disintegrants, SSG's performance is not significantly compromised by the presence of hydrophobic excipients like lubricants, nor is it adversely affected by high tablet compression pressures. This resilience ensures reliable disintegration performance, a critical factor for product consistency and quality. Pharmaceutical manufacturers value this predictability, which simplifies the formulation process and reduces the risk of batch failures.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying SSG that meets the highest industry standards. The production process is carefully controlled to ensure lot-to-batch uniformity, guaranteeing that the sodium starch glycolate disintegrant properties are consistent. This attention to detail is essential for pharmaceutical companies that depend on the predictable performance of their excipients to ensure the efficacy and safety of their finished products. The goal is always to improve tablet bioavailability through the optimal use of such high-quality components.
The application of SSG extends to various types of oral solid dosage forms, including swallowable tablets, orally disintegrating tablets (ODTs), and capsules. In ODTs, its rapid disintegration capability is particularly advantageous, enabling the tablets to dissolve quickly in the mouth, offering convenience to patients who have difficulty swallowing. By facilitating swift and efficient disintegration, SSG plays a critical role in delivering drugs effectively and enhancing patient compliance. NINGBO INNO PHARMCHEM CO.,LTD. provides this essential excipient to support the development of advanced and patient-friendly pharmaceutical products.
Perspectives & Insights
Silicon Analyst 88
“In ODTs, its rapid disintegration capability is particularly advantageous, enabling the tablets to dissolve quickly in the mouth, offering convenience to patients who have difficulty swallowing.”
Quantum Seeker Pro
“By facilitating swift and efficient disintegration, SSG plays a critical role in delivering drugs effectively and enhancing patient compliance.”
Bio Reader 7
“provides this essential excipient to support the development of advanced and patient-friendly pharmaceutical products.”