NINGBO INNO PHARMCHEM CO.,LTD. provides Cyclophosphamide Monohydrate (CAS 6055-19-2), a drug whose pharmacological action is central to its therapeutic efficacy. Understanding how it works is key to appreciating its role in medicine.

Cyclophosphamide Monohydrate is an inactive prodrug. Upon administration, it undergoes metabolic activation, primarily in the liver, through a series of enzymatic transformations. The critical active metabolite is phosphoramide mustard. This potent alkylating agent exerts its cytotoxic effect by attaching alkyl groups to the guanine base of DNA within rapidly dividing cells, including cancer cells and overactive immune cells.

This DNA alkylation leads to DNA strand breaks and cross-linking, ultimately disrupting DNA replication and transcription. The consequence is the induction of apoptosis (programmed cell death) in susceptible cells. This dual action – inhibiting cell proliferation and inducing cell death – is what makes Cyclophosphamide Monohydrate effective against both malignant growths and hyperactive immune responses in autoimmune diseases.

The specificity of its action, while not absolute, is enhanced by the fact that its activation is more pronounced in tissues with higher metabolic activity, such as tumors. NINGBO INNO PHARMCHEM CO.,LTD. ensures the quality of our cyclophosphamide monohydrate API to guarantee that this precise pharmacological action can be reliably achieved in therapeutic settings. For information on cyclophosphamide monohydrate research applications, our team is available to provide technical support.