The pharmaceutical industry relies on the consistent availability of high-purity active pharmaceutical ingredients (APIs) to develop safe and effective medications. Besifloxacin Hydrochloride, a potent fluoroquinolone antibiotic used in ophthalmic formulations, is one such critical API. For pharmaceutical manufacturers and suppliers, understanding the nuances of procuring this chemical is essential for maintaining product quality and regulatory compliance. This guide aims to provide a comprehensive overview of sourcing Besifloxacin Hydrochloride.

The first consideration when procuring Besifloxacin Hydrochloride is its purity. High purity is paramount for APIs, as even trace impurities can affect the efficacy and safety of the final drug product. Reputable suppliers will provide detailed Certificates of Analysis (CoA) that confirm the purity, often measured by High-Performance Liquid Chromatography (HPLC), along with other critical quality parameters such as loss on drying, residue on ignition, and residual solvents. For Besifloxacin Hydrochloride, a purity of 99.02% or higher, as often cited by manufacturers, is indicative of a high-quality grade suitable for pharmaceutical use.

Identifying the correct chemical is also crucial. Besifloxacin Hydrochloride is chemically known as Besifloxacin HCl. Its unique identifier, the CAS number, is 405165-61-9. This CAS number is a globally recognized registry number that unambiguously identifies this specific chemical substance. When ordering or inquiring about the product, referencing this CAS number ensures that the correct Besifloxacin Hydrochloride is being discussed, preventing costly errors. Suppliers should readily provide this information.

When engaging with suppliers for Besifloxacin Hydrochloride, several factors should be evaluated. Beyond purity and CAS number verification, consider the supplier's manufacturing capabilities and certifications. GMP (Good Manufacturing Practice) certification is a vital indicator of quality control and adherence to stringent manufacturing standards. FDA and ISO certifications further validate a supplier's commitment to quality and safety. Understanding the production capacity (e.g., 100kg/Month) helps in planning large-scale manufacturing runs.

Payment terms and international commercial terms (Incoterms) like FOB, CIF, or CPT are also important logistical considerations. Flexible payment options, including LC, T/T, D/P, PayPal, Western Union, and Money Gram, can facilitate smoother transactions. For manufacturers in different regions, understanding these terms ensures that the supply chain is managed efficiently and cost-effectively. The pricing of Besifloxacin Hydrochloride will vary based on quantity, purity, and supplier, making competitive sourcing a key strategy.

In conclusion, procuring Besifloxacin Hydrochloride requires diligence in verifying purity, confirming its CAS number, and assessing supplier credentials. By partnering with GMP-certified manufacturers and understanding the associated logistical and financial aspects, pharmaceutical companies can secure a reliable supply of this essential API, thereby ensuring the quality and availability of critical ophthalmic medications. The continuous demand for effective treatments for bacterial eye infections makes Besifloxacin Hydrochloride a valuable component in the pharmaceutical market, underscoring the importance of strategic procurement.