Sulbutiamine, a synthetic compound derived from Vitamin B1 (thiamine), has garnered attention in both the pharmaceutical and supplement industries. Understanding its chemical properties is fundamental to appreciating its applications and efficacy. This article provides an in-depth look at the science behind Sulbutiamine, from its molecular structure to its practical uses.

Chemically, Sulbutiamine is identified as bis(2-methylpropionate) of thiamine disulfide. Its molecular formula is C32H46N8O6S2, and it possesses a molecular weight of approximately 702.89 g/mol. A key distinguishing feature is its lipophilic nature, meaning it dissolves in fats and oils. This contrasts sharply with thiamine, which is water-soluble. This lipid solubility is the primary reason Sulbutiamine can more easily cross the blood-brain barrier, a critical factor in its effectiveness.

In terms of physical appearance, Sulbutiamine is typically a white to off-white crystalline powder. Its characteristic sulfurous odor is also noted. The melting point usually falls in the range of 128-132°C, and it exhibits pH-dependent solubility, being slightly soluble in water but more soluble in organic solvents like DMSO. The molecule’s structure consists of two modified thiamine molecules linked by a disulfide bridge, with isobutyryl groups attached, enhancing its lipid solubility.

The synthesis of Sulbutiamine involves a multi-step chemical process starting from Vitamin B1. This involves reactions with substances like isobutyric anhydride to create the final dimeric structure. Ensuring high purity, typically above 98% as determined by HPLC, is crucial for its use as a pharmaceutical intermediate or active pharmaceutical ingredient (API).

Sulbutiamine's primary applications stem from its ability to increase thiamine levels in the central nervous system. It is recognized for treating asthenia (physical and mental fatigue) and improving cognitive functions such as memory, attention, and psychomotor speed. It also modulates dopaminergic and glutamatergic neurotransmission. These properties make it a valuable component in the development of nootropic supplements and pharmaceutical formulations targeting neurological health and energy metabolism.

When considering sulbutiamine powder price and availability, sourcing from reliable manufacturers is paramount. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in producing high-quality Sulbutiamine powder, adhering to strict quality control measures. This ensures that the product meets the required specifications for purity and composition, making it suitable for various pharmaceutical and supplement applications. Understanding the chemical intricacies of Sulbutiamine allows for its optimal use in enhancing human health and well-being.