Understanding the precise chemical and physical properties of compounds like 1,2-Dimethyl-5-nitroimidazole (CAS 551-92-8) is fundamental for their effective and safe utilization in research, development, and manufacturing. This white crystalline powder, also known by its common name Dimetridazole, possesses a distinct chemical profile that dictates its behavior and applications.

Chemical Structure and Identification:

The chemical formula for 1,2-Dimethyl-5-nitroimidazole is C5H7N3O2. Its molecular weight is approximately 141.13 g/mol. The structure features an imidazole ring substituted with two methyl groups and a nitro group. The presence of the nitro group is particularly significant, influencing its chemical reactivity and biological activity. The CAS number, 551-92-8, serves as a unique identifier for this specific compound, ensuring clarity in scientific literature and commercial transactions.

Physical Properties:

Dimetridazole typically presents as a white to cream-colored crystalline powder. It has a defined melting point, generally ranging from 137°C to 141°C, which is a key indicator of its purity. The powder form enhances its utility in various chemical processes, allowing for easy weighing and dissolution. Its solubility characteristics and stability under specific conditions are also critical properties that researchers and manufacturers must consider.

Safety and Handling Considerations:

As with many chemical compounds, proper safety protocols are essential when handling 1,2-Dimethyl-5-nitroimidazole. Safety Data Sheets (SDS) typically classify it as causing skin irritation and serious eye irritation, and may carry warnings about potential genetic defects or harm if swallowed. Recommended precautions include:

  • Wearing appropriate personal protective equipment (PPE), such as gloves, protective clothing, and eye protection.
  • Avoiding inhalation of dust or fumes by working in a well-ventilated area or using respiratory protection.
  • Practicing good industrial hygiene, including washing hands thoroughly after handling.

The substance is also noted for being heat-sensitive and air-sensitive, necessitating appropriate storage conditions, often in a refrigerator and under an inert atmosphere, to maintain its quality and prevent degradation.

Reactivity and Incompatibilities:

1,2-Dimethyl-5-nitroimidazole is incompatible with strong oxidizing agents. Handling and storage should ensure separation from such substances to prevent hazardous reactions.

Analytical Information:

The compound's identity and purity are often verified using techniques like HPLC, which provides a precise measure of its assay. Other analytical methods may be employed to check for specific impurities or characteristics, such as ash content and loss on drying, ensuring the product meets rigorous quality standards for its intended applications.

In summary, a thorough understanding of the chemical structure, physical properties, safety precautions, and analytical standards of 1,2-Dimethyl-5-nitroimidazole is crucial for its effective and responsible use in scientific and industrial settings. This knowledge empowers researchers and manufacturers to harness its benefits while mitigating potential risks.