NINGBO INNO PHARMCHEM CO.,LTD. supplies vital pharmaceutical intermediates, and Calcium Folinate (CAS 6035-45-6) stands out for its profound impact on patient care. Chemically, it is the calcium salt of folinic acid, a reduced form of folic acid (Vitamin B9). This structural characteristic allows it to directly participate in essential biochemical pathways without requiring the enzymatic conversion that native folic acid needs, making it a more immediate source of active folate.

This direct biological activity underpins its critical role in cancer therapy. The combination of calcium folinate and fluorouracil chemotherapy exemplifies its utility. By serving as a cofactor for thymidylate synthase, Calcium Folinate potentiates the cytotoxic effects of 5-FU, a widely used anti-cancer drug. This significantly improves treatment outcomes for patients with various malignancies. For researchers and manufacturers looking to buy Calcium Folinate raw material, NINGBO INNO PHARMCHEM CO.,LTD. offers a dependable source of this crucial compound.

Equally important is its function in calcium folinate rescue therapy. When patients receive high doses of methotrexate, a powerful anti-cancer agent that inhibits dihydrofolate reductase, the body’s production of essential folates is halted. This can lead to severe toxicity in healthy cells. Calcium Folinate provides the necessary reduced folates, bypassing the methotrexate block and protecting vital tissues like bone marrow and intestinal lining. This rescue mechanism is a critical component of safe and effective high-dose methotrexate treatment protocols.

Beyond its oncological applications, Calcium Folinate is also employed in managing certain hematological conditions, particularly calcium folinate for megaloblastic anemia caused by folate antagonists. These drugs interfere with the body’s folate metabolism, leading to impaired DNA synthesis and the production of abnormal red blood cells. Calcium Folinate directly addresses this deficiency, aiding in the restoration of normal hematopoiesis.

The quality of pharmaceutical ingredients is paramount. NINGBO INNO PHARMCHEM CO.,LTD. ensures that their high purity calcium folinate powder meets the exacting standards required for pharmaceutical manufacturing, thereby supporting the development of safe and effective treatments. Their commitment to quality makes them a trusted partner in the healthcare supply chain.