The creation of effective pharmaceuticals relies on a deep understanding of chemistry and meticulous synthesis processes. Roxadustat, known scientifically by its CAS number 808118-40-3, is a prime example of a complex molecule with significant therapeutic implications, particularly in the treatment of anemia. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing access to this vital Active Pharmaceutical Ingredient (API), supporting the scientific community’s efforts in understanding its production and application.

Chemically, Roxadustat is an N-acylglycine, derived from the condensation of glycine with a substituted isoquinoline carboxylic acid. Its molecular formula is C19H16N2O5, and it has a molecular weight of 352.34 g/mol. The compound typically presents as a white to off-white crystalline powder, a characteristic that underscores the importance of controlled synthesis and purification in pharmaceutical API manufacturing. The precise chemical structure and high purity are critical for its intended pharmacological activity as a hypoxia-inducible factor (HIF) prolyl-hydroxylase inhibitor.

The synthesis of Roxadustat is a multi-step process, often involving sophisticated organic chemistry techniques. While specific proprietary synthesis routes vary among manufacturers, they generally focus on building the core isoquinoline structure and attaching the necessary functional groups, including the phenoxy and glycine moieties. Each step requires careful control of reaction conditions, reagents, and purification methods to achieve the desired yield and purity. This intricate chemical pathway highlights why robust pharmaceutical intermediate sourcing is so crucial for reliable production.

For companies looking to buy Roxadustat, understanding the synthesis process provides insight into the quality and consistency of the product. NINGBO INNO PHARMCHEM CO.,LTD. adheres to strict quality control protocols throughout its Roxadustat API synthesis operations. This commitment ensures that the final product meets the rigorous standards required for pharmaceutical research and development, enabling its use in sensitive applications such as clinical trials and the formulation of new drug products.

The development of Roxadustat represents a triumph of medicinal chemistry and process development. As research into HIF pathway modulators continues, the demand for high-quality Roxadustat is expected to grow. NINGBO INNO PHARMCHEM CO.,LTD. is well-positioned to meet this demand, offering a reliable supply of this critical compound. Our expertise in pharmaceutical intermediate sourcing and API manufacturing makes us a trusted partner for organizations driving innovation in healthcare.