NINGBO INNO PHARMCHEM CO.,LTD. provides essential pharmaceutical raw materials, including Calcium Folinate (CAS 6035-45-6), a compound critical for both cancer treatment and the management of certain anemias. Understanding its mechanism of action and diverse applications is key for healthcare professionals and researchers alike.

The primary function of Calcium Folinate lies in its ability to act as a metabolic precursor to tetrahydrofolate, the active form of folic acid. This makes it invaluable in two primary scenarios: enhancing the efficacy of certain chemotherapeutic agents and counteracting the toxicity of others. In combination chemotherapy, the calcium folinate and fluorouracil chemotherapy interaction is well-documented. Calcium Folinate stabilizes the binding of 5-FU's active metabolite to thymidylate synthase, a crucial enzyme in DNA synthesis, thereby increasing the drug's potency against rapidly dividing cancer cells. This synergistic effect is a cornerstone in treating various gastrointestinal malignancies.

Furthermore, Calcium Folinate plays a vital role in calcium folinate rescue therapy, particularly following high-dose methotrexate administration. Methotrexate is a folate antagonist that inhibits dihydrofolate reductase, halting the production of active tetrahydrofolate. While effective against cancer cells, it can also harm healthy cells. Calcium Folinate bypasses this inhibition, providing essential folate cofactors to normal cells and thus “rescuing” them from methotrexate-induced toxicity. This ‘leucovorin rescue’ is a critical safety measure in high-dose methotrexate protocols.

For individuals suffering from specific types of anemia, the therapeutic benefits of Calcium Folinate are also significant. It is used to treat megaloblastic anemia, especially when caused by folate antagonists that interfere with folate metabolism. While less common than folic acid for simple folate deficiency, its injectable form offers a critical advantage in cases of malabsorption or when rapid correction is necessary. Patients and clinicians seeking to understand the use of calcium folinate for megaloblastic anemia will find its role in restoring healthy red blood cell production invaluable.

For manufacturers and researchers, sourcing high-quality Calcium Folinate is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted provider of high purity calcium folinate powder, ensuring that its clients receive materials that meet rigorous pharmaceutical standards. The ability to buy Calcium Folinate raw material from a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. is essential for the consistent production of life-saving medications and the successful execution of complex medical treatments.