NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of providing advanced research chemicals, and one such compound generating significant interest is Cilengitide. This molecule, a potent and selective inhibitor of integrins αvβ3 and αvβ5, holds substantial promise in the field of targeted cancer therapy. Understanding its mechanism and potential applications is crucial for researchers and clinicians alike.

Integrins are a class of cell surface receptors that play vital roles in cell-cell and cell-extracellular matrix adhesion. Specifically, integrins αvβ3 and αvβ5 are overexpressed in many types of tumors and are critical for processes such as angiogenesis (the formation of new blood vessels), tumor cell invasion, and metastasis. By targeting these integrins, Cilengitide offers a strategic approach to disrupting tumor growth and spread. The ability to purchase Cilengitide from a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. is essential for advancing research in this area.

The development of Cilengitide has been a collaborative effort, originating from research at the Technical University of Munich and Merck KGaA. Its design is based on the cyclic peptide cyclo(-RGDfV-), which mimics the natural ligand sequence (Arg-Gly-Asp) recognized by these integrins. This molecular mimicry allows Cilengitide to effectively bind to and block the activity of αvβ3 and αvβ5 integrins, thereby inhibiting their pro-tumorigenic functions. Researchers often search for 'selective integrin antagonist' when looking for compounds like Cilengitide, highlighting the specific nature of its therapeutic action.

Cilengitide's potential is particularly evident in its investigation for treating glioblastoma, an aggressive form of brain cancer. The compound has shown the ability to inhibit angiogenesis within tumors and influence tumor invasion and proliferation. While clinical trials have yielded varying results, the ongoing research into cilengitide for glioblastoma treatment continues. The prospect of improved patient outcomes through targeted therapies remains a significant driving force.

For those looking to buy Cilengitide, NINGBO INNO PHARMCHEM CO.,LTD. provides a source for this critical research chemical. The availability of high-purity Cilengitide is paramount for reproducible experimental results and advancing our understanding of its therapeutic benefits. The search for 'high quality Cilengitide supplier' often leads to trusted sources that can guarantee the integrity and efficacy of the product for research purposes.

In conclusion, Cilengitide represents a significant development in the pursuit of targeted cancer therapies. Its ability to inhibit key integrins involved in tumor progression makes it a valuable tool for research and a potential therapeutic agent for various cancers. NINGBO INNO PHARMCHEM CO.,LTD. is proud to support this research by providing access to this vital compound.