The effective and safe use of chemotherapy drugs like Fluorouracil (5-FU) often relies on understanding individual patient factors that can influence drug metabolism and toxicity. Among these, Dihydropyrimidine Dehydrogenase (DPD) deficiency stands out as a crucial consideration for patients undergoing 5-FU treatment. At NINGBO INNO PHARMCHEM CO.,LTD., we recognize the importance of this aspect of patient care and are committed to providing insights that support informed treatment decisions.

DPD is an enzyme naturally present in the body that plays a primary role in breaking down pyrimidines, including the chemotherapy drug 5-FU. When an individual has a DPD deficiency, their body is unable to metabolize 5-FU efficiently. This means that the drug can accumulate in the system, leading to a significantly increased risk of severe, and potentially life-threatening, toxicities. These toxicities can manifest in various ways, including severe gastrointestinal issues (like mucositis and diarrhea), bone marrow suppression (leading to neutropenia and increased infection risk), neurotoxicity, and severe skin reactions.

Genetic variations in the DPYD gene are the most common cause of DPD deficiency. These variations can result in reduced or absent DPD enzyme activity. While most people have normal DPD activity, a small percentage of the population (estimated to be around 0.2% to 0.5%) have complete DPD deficiency, and a larger percentage have partial deficiency. Without proper screening, individuals with DPD deficiency may receive standard doses of 5-FU, leading to adverse reactions.

To mitigate these risks, proactive DPD testing is increasingly becoming a standard part of the pre-treatment evaluation for patients scheduled to receive 5-FU or other fluoropyrimidine-based chemotherapies. This testing can be done through a blood test that analyzes the DPYD gene for specific mutations or by measuring the actual DPD enzyme activity. Based on the test results, healthcare providers can adjust the 5-FU dosage, starting with a lower dose for those with partial deficiency or considering alternative treatment options for individuals with complete deficiency. This personalized approach is crucial for ensuring patient safety and optimizing treatment outcomes.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting the safe and effective use of 5-Fluorouracil. We understand the critical nature of pharmaceutical quality and the importance of informed patient care. When considering the buy 5-fluorouracil process, it is essential to partner with suppliers who prioritize quality and provide comprehensive information. We ensure our 5-FU price reflects the high standards of our product, enabling healthcare professionals to administer this vital medication with confidence.