Gout is a complex form of inflammatory arthritis characterized by the deposition of monosodium urate crystals in joints and tissues, primarily due to elevated levels of uric acid in the blood, a condition known as hyperuricemia. For many years, the primary approach to managing hyperuricemia involved xanthine oxidase inhibitors (XOIs) like allopurinol and febuxostat. However, a significant portion of patients do not achieve their target uric acid levels with XOIs alone. This is where advanced therapeutic agents like Lesinurad come into play.

Lesinurad, with the CAS number 878672-00-5, is a pharmaceutical active ingredient that functions as a selective uric acid reabsorption inhibitor (SURI). Developed by NINGBO INNO PHARMCHEM CO.,LTD., Lesinurad targets specific transporters in the kidneys, namely URAT1 and OAT4. By inhibiting these transporters, Lesinurad increases the amount of uric acid excreted in the urine, thereby effectively reducing serum uric acid levels. This mechanism of action is crucial for patients who require an additional strategy to manage their gout and hyperuricemia.

The therapeutic benefit of Lesinurad is most pronounced when used in conjunction with XOIs. This combination therapy has shown to be more effective in achieving target serum uric acid levels compared to XOI monotherapy. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of this synergistic approach, as highlighted in studies exploring Lesinurad drug interactions and treatment protocols. The precise Lesinurad dosage is typically determined by a healthcare professional, often involving a 200 mg once-daily administration alongside the patient's prescribed XOI.

While Lesinurad offers significant therapeutic advantages, understanding its potential Lesinurad side effects is also important for patients and healthcare providers. Common side effects may include headache, flu-like symptoms, and heartburn. More serious, though less frequent, effects can involve kidney-related issues, especially if the medication is not used as prescribed or in combination with an XOI. This underscores the necessity of consulting with specialists and carefully adhering to medical advice when considering buy Lesinurad online or integrating it into a treatment plan.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality Lesinurad for pharmaceutical research and development. As a key player among Lesinurad suppliers, the company ensures that its product meets stringent purity standards, typically exceeding 99% assay. This focus on quality is paramount for its application in treating serious conditions like gout. For those seeking effective gout treatment, understanding the role of agents like Lesinurad is key. NINGBO INNO PHARMCHEM CO.,LTD. continues to contribute to advancements in pharmaceutical chemistry, offering reliable sources for critical APIs and intermediates.