Piperazine (CAS 110-85-0) is a fascinating organic compound with a cyclic diamine structure that underpins its diverse applications. NINGBO INNO PHARMCHEM CO.,LTD. is deeply involved in understanding and harnessing the chemical properties of this versatile molecule.

Chemically, Piperazine is characterized by its white, crystalline solid appearance and its significant hygroscopic nature, meaning it readily absorbs moisture from the air. It exhibits strong alkalinity, with a 10% aqueous solution typically showing a pH between 10.8 and 11.8. Its solubility in water and glycerol is high, while it is less soluble in ethanol and insoluble in ether. This solubility profile is crucial for many of its applications, especially in aqueous-based formulations and synthetic processes.

The synthesis of Piperazine commonly involves the reaction between ethylenediamine and 1,2-dichloroethane, or through the dimerization of amino-ethanol at high temperatures. These methods allow for the production of Piperazine with high purity, a critical factor for its use as a pharmaceutical intermediate and in other sensitive chemical processes. The ability to achieve an assay of 99%min is a hallmark of quality production, as maintained by NINGBO INNO PHARMCHEM CO.,LTD.

Piperazine's reactivity stems from its two secondary amine groups. It readily undergoes reactions typical of amines, such as N-alkylation, leading to mono- or di-substituted derivatives depending on reaction conditions. It also forms salts with both inorganic and organic acids, many of which have important pharmaceutical applications, as seen in the piperazine citrate and phosphate production.

Understanding these fundamental chemical properties and synthesis routes is essential for optimizing the use of Piperazine. For industries leveraging its capabilities, whether as a piperazine anthelmintic intermediate or in other chemical synthesis, knowledge of its behavior is paramount. NINGBO INNO PHARMCHEM CO.,LTD. continuously works to ensure the reliable supply and consistent quality of Piperazine, supporting advancements across various chemical disciplines.