At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to providing comprehensive information about the active pharmaceutical ingredients we supply, including Sulfadoxine. Sulfadoxine (CAS 2447-57-6) is a sulfonamide antibiotic that operates through a distinct mechanism of action, primarily targeting the folate synthesis pathway. This pathway is critical for the survival of many bacteria and protozoa, including the malaria parasite Plasmodium falciparum.

The Sulfadoxine antibiotic mechanism involves acting as a competitive inhibitor of the enzyme dihydropteroate synthetase (DHPS). Bacteria and protozoa synthesize folic acid, a vital nutrient for the production of nucleic acids and proteins, using this enzyme. Sulfadoxine structurally resembles para-aminobenzoic acid (PABA), a natural substrate for DHPS. By binding to DHPS, Sulfadoxine prevents PABA from binding, thereby blocking the production of dihydrofolic acid. This disruption leads to a deficiency in essential building blocks, ultimately inhibiting microbial growth and replication.

This understanding is crucial when evaluating Sulfadoxine vs pyrimethamine efficacy, as pyrimethamine targets a downstream enzyme, dihydrofolate reductase (DHFR), in the same pathway. The combined inhibition of both enzymes by Sulfadoxine and pyrimethamine provides a powerful synergistic effect, making them highly effective in treating malaria. NINGBO INNO PHARMCHEM CO.,LTD. provides Sulfadoxine for these critical combination therapies.

The pharmaceutical applications of Sulfadoxine extend beyond malaria. It is also employed in treating various bacterial infections, such as urinary tract infections and respiratory infections. Sourcing Sulfadoxine pharmaceutical grade from reliable Sulfadoxine suppliers in China like NINGBO INNO PHARMCHEM CO.,LTD. ensures that manufacturers receive a product of consistent purity and quality, vital for producing safe and effective medications. The availability and competitive Sulfadoxine 2447-57-6 price further enhance its accessibility for global pharmaceutical production.

For companies looking to buy Sulfadoxine online, choosing a reputable manufacturer is essential. NINGBO INNO PHARMCHEM CO.,LTD. stands as a trusted source for high-quality Sulfadoxine, supporting the development of vital pharmaceuticals worldwide.