At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to supplying researchers with high-quality biological reagents that unlock new avenues of discovery. Holo-Transferrin is one such crucial protein, celebrated for its multifaceted roles in biological systems.

Holo-Transferrin, the iron-saturated form of transferrin, is primarily known for its function as the main iron-transporting protein in the plasma of vertebrates. It plays an indispensable role in delivering iron from absorption sites in the intestine or release from macrophages to the bone marrow for erythropoiesis, and to all other cells for various metabolic needs. Understanding the cellular iron uptake mechanism is key to appreciating Holo-Transferrin's importance; it binds to specific receptors on cell surfaces, facilitating the entry of iron into the cell through receptor-mediated endocytosis. This regulated delivery is critical for preventing iron overload and deficiency.

Beyond iron transport, Holo-Transferrin exhibits significant antioxidant properties. By binding iron, a metal that can catalyze the formation of reactive oxygen species (ROS), transferrin helps to mitigate oxidative stress within the body. This protective function is vital for cellular health and preventing damage to DNA, proteins, and lipids. The contribution of Holo-Transferrin to the roles of transferrin in cell proliferation is also substantial; iron is a critical cofactor for enzymes involved in DNA synthesis and cell division, making adequate iron supply, facilitated by Holo-Transferrin, essential for healthy cell growth.

Furthermore, Holo-Transferrin is involved in the bactericidal function of transferrin, a component of the innate immune system. By sequestering iron, a nutrient essential for bacterial growth, transferrin limits microbial proliferation, thus acting as a natural defense against infections. Researchers studying iron transport protein for biological research leverage Holo-Transferrin to investigate these complex immune and metabolic pathways.

For laboratories, the availability of recombinant human holo-transferrin for cell culture from trusted suppliers like NINGBO INNO PHARMCHEM CO.,LTD. offers a consistent and reliable source of this vital protein. This ensures that experimental protocols involving cell growth and metabolic studies can be conducted with high precision and reproducibility. The commitment of NINGBO INNO PHARMCHEM CO.,LTD. to providing high-purity reagents underscores the importance of such proteins in advancing scientific understanding across various disciplines.