NINGBO INNO PHARMCHEM CO.,LTD. delves into the fundamental chemistry behind Musk Ambrette (CAS 83-66-9), a synthetic nitro musk that has left a notable mark on the fragrance and flavor industries. Understanding its chemical properties is crucial for appreciating its historical applications and the reasons behind its current regulatory status.

Chemically, Musk Ambrette is classified as a nitro musk, characterized by the presence of nitro groups within its molecular structure. Its molecular formula is C12H16N2O5, and it possesses a molecular weight of approximately 268.27 g/mol. In its pure form, it typically appears as pale yellowish to yellow crystals. Key physical properties include a melting point range of 84-86°C and a boiling point of 185°C at 16 mmHg. It exhibits limited solubility in water but is soluble in organic solvents like ethanol and ether, a characteristic that facilitated its incorporation into various formulations.

Historically, Musk Ambrette was prized for its pleasant odor profile – a complex blend described as sweet, floral, and reminiscent of ambrette seeds. This made it a popular choice as a fixative in perfumes and a flavoring agent in certain applications. Its stability and strong scent throw contributed to its widespread adoption across different product categories, including cosmetics, soaps, and detergents.

However, extensive research has identified potential health concerns associated with nitro musks, specifically photosensitization and neurotoxicity. These findings have led to recommendations from bodies like the International Fragrance Association (IFRA) to restrict or prohibit its use in consumer products. While its direct application is now limited, studying the chemical properties and past industrial uses of Musk Ambrette provides valuable context for the development and safety assessment of aroma chemicals. NINGBO INNO PHARMCHEM CO.,LTD. remains dedicated to providing comprehensive information on chemical ingredients and ensuring adherence to global safety standards.