10-Bromodecanol, identified by its CAS number 53463-68-6, is a significant chemical intermediate that serves as a versatile building block in organic synthesis. Its structure, featuring a ten-carbon chain with a hydroxyl group at one end and a bromine atom at the other, imparts dual reactivity, making it highly valuable for constructing complex organic molecules. Available as a clear yellow liquid, its physical and chemical properties are well-understood, facilitating its widespread use across various scientific disciplines.

The synthesis of 10-Bromodecanol typically commences with 1,10-decanediol. Through a process of selective monobromination, often employing hydrobromic acid under controlled temperature and concentration, the desired compound is produced. Optimization of these conditions is crucial to achieve high yields and purity, minimizing the formation of unwanted byproducts such as 1,10-dibromodecane. Advanced techniques, including the use of phase transfer catalysts and microwave irradiation, have been developed to enhance reaction efficiency and reduce synthesis times, reflecting an ongoing effort to improve synthetic methodologies.

The reactivity of 10-Bromodecanol is attributed to its two distinct functional groups. The primary alcohol group can participate in a variety of reactions, including oxidation to aldehydes or carboxylic acids, esterification, and ether formation. Simultaneously, the bromine atom acts as an excellent leaving group, enabling nucleophilic substitution reactions. This allows for the introduction of a wide range of substituents, facilitating the synthesis of diverse organic compounds with tailored properties. For example, the bromine can be readily substituted by azide ions to form 10-azidodecanol or converted to other functionalities through various cross-coupling reactions.

The applications of 10-Bromodecanol are broad and impactful. It is a critical intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its utility extends to more specialized areas, such as the creation of insect pheromones, which are vital for integrated pest management, and the construction of complex supramolecular structures like rotaxane dendrimers. It also serves as a precursor for molecules that exhibit biological activity, such as those that induce neurite outgrowth, indicating its potential in neuroscience research and therapeutic development. The consistent quality and availability of 10-Bromodecanol, supported by suppliers like NINGBO INNO PHARMCHEM CO.,LTD., are essential for researchers and industries relying on this versatile chemical building block for innovation and product development.