NINGBO INNO PHARMCHEM CO.,LTD. provides this guide to 3-Bromo-4-methylpyridine (CAS 3430-22-6), a vital intermediate in organic synthesis, outlining its key characteristics, proper handling, and sourcing recommendations. Understanding these aspects is crucial for chemists and researchers utilizing this versatile compound.

Physical and Chemical Properties:

3-Bromo-4-methylpyridine, also recognized as 3-Bromo-4-picoline, is typically presented as a colorless to light yellow liquid. Its molecular formula is C6H6BrN, with a molecular weight of approximately 172.02 g/mol. Key physical properties include a density of around 1.5 g/cm³, a boiling point of roughly 198-200 °C at standard atmospheric pressure, and a refractive index of approximately 1.553. The flash point is around 74.1 °C, indicating moderate flammability. Its vapor pressure is relatively low at room temperature, suggesting it is not highly volatile but should still be handled in well-ventilated areas.

Applications in Synthesis:

The primary application of 3-Bromo-4-methylpyridine is as an intermediate in organic synthesis. It serves as a critical building block for creating more complex molecular structures, particularly within the pharmaceutical and agrochemical industries. Its reactive bromine atom facilitates various coupling reactions, making it a versatile tool for synthesizing active pharmaceutical ingredients (APIs), herbicides, fungicides, and other fine chemicals. Researchers also utilize it in studies related to heterocyclic chemistry and material science.

Safe Handling and Storage:

To ensure the stability and safety of 3-Bromo-4-methylpyridine, proper handling and storage are essential. It should be stored in a cool, dry, and well-ventilated place, away from sources of ignition, heat, and direct sunlight. Containers should be kept tightly sealed to prevent moisture absorption and evaporation. When handling, it is advisable to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and protective clothing, to avoid skin and eye contact or inhalation. Referencing the Safety Data Sheet (SDS) for specific hazard information and emergency procedures is strongly recommended.

Sourcing Considerations:

When sourcing 3-Bromo-4-methylpyridine, particularly for industrial or research applications, it is crucial to partner with reputable manufacturers and suppliers. Companies like NINGBO INNO PHARMCHEM CO.,LTD., a leading 3-Bromo-4-methylpyridine supplier in China, offer products with guaranteed high purity (e.g., ≥98.0% assay). This ensures consistency and reliability in your synthetic processes. Factors to consider when choosing a supplier include product quality, availability, packaging options (often in 200 kg drums or customized), and the provision of essential documentation like Certificates of Analysis (COA).

By understanding the properties, safe handling procedures, and reliable sourcing options for 3-Bromo-4-methylpyridine, researchers and manufacturers can effectively leverage this intermediate to drive innovation. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting the chemical industry with high-quality products and expert guidance. For inquiries about purchasing 3-Bromo-4-methylpyridine or exploring custom synthesis services, please contact us.