The world of chemistry is built upon a foundation of versatile intermediates that enable the creation of complex and functional molecules. 4-Sulfophenyl Isothiocyanate Sodium Salt Monohydrate (SPI) is one such indispensable compound, widely recognized for its utility in organic synthesis. As a leading provider of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. offers this essential building block, ensuring high purity and reliable performance for diverse chemical needs.

The synthesis of SPI typically involves the sulfonation of phenyl isothiocyanate, followed by neutralization with sodium hydroxide to form the sodium salt, which is then crystallized as a monohydrate. This process yields a white to off-white powder with an assay of ≥99.0%, indicative of its suitability for demanding applications. The presence of the isothiocyanate group (-N=C=S) is key to its reactivity. This group is electrophilic and readily undergoes nucleophilic addition reactions, most notably with primary and secondary amines. This reaction forms stable thiourea derivatives, a transformation that is fundamental to many of its applications.

The sulfonate group (-SO3Na) plays a critical role in enhancing the compound's solubility in water and other polar solvents. This aqueous compatibility is a significant advantage, allowing reactions to be performed in environmentally friendly conditions or in biological buffer systems. The synergy between the reactive isothiocyanate moiety and the solubilizing sulfonate group makes SPI particularly valuable for applications such as bioconjugation, where precise control over reaction conditions and product solubility is essential.

At NINGBO INNO PHARMCHEM CO.,LTD., we provide this vital intermediate to researchers and manufacturers who require dependable materials for their synthetic endeavors. Whether you are developing new pharmaceuticals, designing novel materials, or conducting intricate biochemical experiments, our high-quality SPI can serve as a crucial component in your workflow. Our commitment to stringent quality control ensures that each batch meets rigorous specifications, facilitating reproducible results and efficient chemical processes. When you purchase from us, you are not just buying a chemical; you are investing in a reliable partner for your chemical supply needs.

The reactivity of SPI extends to various scientific research applications. It is employed in protein modification studies, aiding in enzyme characterization and structural analysis. Furthermore, its ability to react with amine-functionalized surfaces makes it useful in creating modified nanoparticles for drug delivery or as biosensors. The detailed understanding of its synthesis and reactivity allows chemists to harness its potential effectively, driving progress in areas like medicinal chemistry, materials science, and analytical techniques. NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply this foundational chemical, empowering innovation through quality and expertise.