N-Phenyl(trifluoromethane)sulfonamide, identified by CAS 456-64-4, stands as a cornerstone intermediate in modern organic chemistry. Its unique structure, combining an aniline framework with a trifluoromethanesulfonyl group, grants it specific reactivity and characteristics that are invaluable for synthesizing a wide range of complex molecules. Understanding its synthesis and properties is crucial for its effective utilization.

The N-Phenyl(trifluoromethane)sulfonamide synthesis typically involves the reaction of trifluoromethanesulfonic anhydride with aniline. This acid-catalyzed reaction is a classic example of sulfonylation, where the aniline nitrogen atom acts as a nucleophile attacking the electrophilic sulfur atom of the anhydride. The resulting product, N-Phenyl(trifluoromethane)sulfonamide, is a stable, crystalline solid, usually appearing as a white powder, with a purity often exceeding 98.0%. These N-Phenyl(trifluoromethane)sulfonamide properties make it an attractive intermediate for industrial applications.

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The trifluoromethanesulfonyl group itself is highly electronegative and electron-withdrawing, influencing the chemical behavior of the molecule it is attached to. This characteristic is leveraged in medicinal chemistry to modify drug solubility, binding affinity, and metabolic stability. In essence, N-Phenyl(trifluoromethane)sulfonamide acts as a convenient vehicle for introducing this critical functional group.

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In conclusion, N-Phenyl(trifluoromethane)sulfonamide is a vital intermediate due to its accessible synthesis and valuable chemical properties. Its role in advancing fields like pharmaceuticals and materials science underscores its importance. NINGBO INNO PHARMCHEM CO.,LTD. remains dedicated to providing the highest quality N-Phenyl(trifluoromethane)sulfonamide to fuel scientific discovery and industrial innovation.