Understanding the synthesis and intrinsic properties of key chemical intermediates is fundamental to advancing research and industrial applications. 1,4-Phenylenebisboronic acid (CAS 4612-26-4) is a prime example of such a compound, serving as a versatile building block in organic synthesis and materials science. This article provides a comprehensive overview of its production methods, characteristic properties, and essential handling information. NINGBO INNO PHARMCHEM CO., LTD. is committed to providing high-quality chemical products, including this vital reagent.

The synthesis of 1,4-Phenylenebisboronic acid typically begins with readily available precursors. A common route involves the metallation of 1,4-dibromobenzene or 1,4-diiodobenzene. This is often achieved through reaction with an organolithium reagent or by forming a Grignard reagent. The resulting arylmetal species is then reacted with a borate ester, such as trimethyl borate or triisopropyl borate. The intermediate boronate ester is subsequently hydrolyzed under acidic conditions to yield the desired 1,4-phenylenebisboronic acid. This process demands meticulous control over reaction temperatures and inert atmosphere to prevent side reactions and ensure high purity of the final product.

Key properties of 1,4-Phenylenebisboronic acid include its molecular formula, C6H8B2O4, and a molecular weight of approximately 165.75 g/mol. Physically, it is typically described as a white to off-white crystalline powder. Its melting point is notably high, often reported as greater than 350°C, indicating a stable solid structure. Solubility characteristics are also important; it is generally soluble in polar organic solvents like methanol and exhibits some solubility in water. These physical and chemical attributes dictate its handling and application in various synthetic procedures.

Handling 1,4-Phenylenebisboronic acid requires adherence to standard laboratory safety practices. As with many fine chemicals, it is advisable to wear appropriate personal protective equipment, including gloves, eye protection, and a lab coat. It should be stored in a cool, dry, and well-ventilated area, preferably in a tightly sealed container to prevent moisture absorption, which can lead to the formation of anhydrides. While not typically classified as highly hazardous, appropriate safety data sheets (SDS) should always be consulted before use.

The utility of 1,4-Phenylenebisboronic acid spans across multiple fields. In pharmaceutical synthesis, it serves as a critical intermediate for building complex drug molecules via Suzuki-Miyaura cross-coupling reactions. In materials science, it is used to synthesize conjugated polymers, OLED materials, and porous frameworks, leveraging its bifunctional nature to create ordered molecular structures. Its consistent performance in these applications underscores the importance of its reliable synthesis and purification.

NINGBO INNO PHARMCHEM CO., LTD. is dedicated to providing researchers and industries with access to high-quality chemical reagents. Our commitment to excellence in synthesis and quality control ensures that our 1,4-Phenylenebisboronic acid is suitable for even the most demanding applications. For inquiries or to purchase this essential compound, please contact our sales team.